Drew Endy uses DNA to make new and improved versions of life.
When Drew Endy envisions the future, he sees giant gourds engineered to grow into four-bedroom, two-bathroom houses. He sees people alerted to nascent tumors in their bodies by internal biological sensors, and cars fueled by bacteria-produced gasoline. Endy, 37, is a pioneer in synthetic biology, a field that combines biology, chemistry, and engineering to remake biological systems to act according to human design. In other words, he's a little like God, if God were a geek.For Endy, who has roots in civil and environmental engineering, biology offers the most sophisticated building materials in the world, potentially far more useful than anything created by modern technology. Endy is attempting to create a biological programming language by identifying, cataloging, and standardizing small sequences of DNA that tell a cell to perform a specific task.After joining the faculty at MIT, in 2004, Endy co-founded the Registry of Standard Biological Parts, an open-source catalogue of DNA segments with specific functions, such as those that make DNA strands fold into shapes like microscopic origami or cause cells to change color. These "BioBrick" parts, as Endy calls them, are fitted with special links at either end where they may be easily connected with other DNA segments, much in the manner of lego blocks. The segments snap together to form more complex instructions, so that scientists can manipulate exactly what task a cell performs. "We've started to collect genetic words that speak to the cell and tell it to do something," he says. For example, Endy's colleague Jay Keasling has found a way to reengineer E. coli so that they naturally produce an anti-malaria drug. Soon, huge vats of bacteria will be making the medicine, at a fraction of the current cost.\n\n\n
|He's a little like God, if God were a geek.|
</td><td style="border-top: 1px solid #898989; border-right: 1px solid #898989; border-bottom: 1px solid #898989; padding: 8px; background-color: #faf7fb"><em><strong>Endy and</strong> some MIT colleagues started the <a href="http://parts2.mit.edu/wiki/index.php/Main_Page" target="_blank">International Genetically Engineered Machine</a> competition, in which student teams engineer living systems. In 2006, one team made bacteria that changes color when it detects arsenic in well water.</em></td></tr></tbody></table> In fact, Endy believes that the best counter to these risks is for the synthetic biologists not to shy away from the potentially dangerous research, but rather to help ensure that it is used in the right way. Endy takes this a step further, by promoting a free, open exchange of information about DNA sequences, allowing synthetic biologists to focus on problems-solving rather than profit, and closely monitor any impending disasters. To that end, he also serves as president of the BioBricks Foundation, an organization of scientists and legal experts working to develop technical standards and legal protections for genetic sequences. "When we arrive at the future with a first generation of parts that can work together," he says, "we'll have the parts open and free, and people will be able to build what they want." And Endy has many ideas about what that future will look like: "Imagine large-scale cities grown from bio-matter," he muses. "Or, how about bacteria that smell like bananas? That sounds nice."<strong>LEARN MORE</strong><a href="http://openwetware.org/wiki/Endy_Lab">openwetware.org/wiki/Endy_Lab</a><strong>MAKE UP</strong>Justin St. Clair/Exclusive Artists
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