Japanese researchers invent game-changing drug that could help grow back teeth

Researchers have discovered an antibody drug that can hopefully regrow teeth and work wonders on dental conditions.

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Neha B.

Aug 28, 2024

By Neha B.

August 28, 2024

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Array – Photo credit: Representative Cover Image Source: Pexels | Cottonbro Studio, The Mainichi | Dr. Katsu Takahashi

It is said that every tooth in a man’s head is worth more than a diamond, perhaps that’s the reason children dream of tooth fairies. While we may have outgrown the legend of tooth fairies, the possibility of growing back teeth appears to be coming true. Thankfully a group of Japanese researchers and dentists have made a remarkable discovery that will enable the regrowth of teeth in a human being. The medical company, Toregem Biopharma, funded by Kyoto University, is developing a “tooth regeneration antibody drug” based on the research results of Dr. Katsu Takahashi, Oral and Maxillofacial Surgery, Kyoto University. “The idea of growing new teeth is every dentist’s dream,” company co-founder Dr. Takahashi, told Japanese newspaper The Mainichi. “I’ve been working on this since I was a graduate student.”

Representative Image Source: Pexels | Anna Shvets

During the span of their research, the first breakthrough came in the year 2007, according to Toregem Biopharma’s development project report, when a model mouse with supernumerary teeth (more teeth than usual) was discovered. USAG-1 gene deficiency was found to be the cause of these supernumerary teeth in the model mouse. Based on the findings from the mouse, they concluded that teeth could be regenerated in humans with congenital or acquired tooth defects by inactivating the USAG-1 protein with a drug. To test this hypothesis, they used anti-USAG-1 antibodies to check the biological activity of antibodies. In the current scenario, this experiment is focused on patients affected by a condition called anodontia, a genetic disorder resulting from the lack of a full set of adult teeth, or partial anodontia, that is, lacking some teeth. “A single systemic administration of a neutralizing antibody can generate a whole tooth,” according to the tooth-regeneration research published in the Science Advances journal.

Representative Image Source: Pexels | Cedric Fauntleroy

While animals including sharks, lizards and some reptilian species can continuously regrow teeth, it’s been assumed that humans only grow two sets of teeth in their lifetime, but, there is evidence that humans also have dormant “buds” for a third set, a fact also elaborated by My Modern Met. The team created an antibody drug that inhibits the protein that suppresses the growth of teeth. The drug works on these buds and stimulates their growth.

Typically, patients suffering from dental disorders have no other treatment option than implants, but if this study works out, it will churn a new alternative and possibility to treat these dental conditions. The study co-author Manabu Sugai of the University of Fukui, explained, “Conventional tissue engineering is not suitable for tooth regeneration. Our study shows that cell-free molecular therapy is effective for a wide range of congenital tooth agenesis,” as quoted in the official research publication of Fukui University.

According to The Japan Times, the team plans to hold a clinical trial for the drug in 2025 for children between 2 and 6 years of age, children who are born with the lack of some or all permanent teeth. The children will be injected with one dose to induce teeth growth. The clinical trials for this newfangled research are expected to start in the year 2024, but according to IFL Science, as for now, the researchers say that they are planning to repeat the experiment on other mammals such as pigs and dogs.

Editor’s note: This article was originally published on January 19, 2024. It has since been updated.

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The earth has a pulse and science isn't sure why. – Photo credit: Representative Cover Image Source: Pexels | Adrien Olichon| Edited

Environment, Past Events, Pubninja

Scientists puzzled by Earth’s ‘heartbeat’ that causes tremors every 26 seconds

All explanations including ocean waves, volcanoes, and fractured sediments have been ruled out, leaving the mystery behind seismic tremors every 26 seconds unsolved.

GOOD Staff

8/3/2025

Although Earth might seem like a stable, flat surface where we live our lives, seismologists have discovered that it’s far from passive. In fact, Earth has a ‘heartbeat’ that pulses every 26 seconds, according to Discover Magazine. Known as “microseisms,” these faint seismic tremors resemble tiny earthquakes, though they aren’t exactly the same. For decades, scientists have been baffled by these mysterious tremors, and despite many theories, no definitive explanation has been found.
Representative Image Source: Unsplash | NASA
In humans, a heartbeat is produced by electrical signals that cause the heart muscles to contract and expand. But for Earth, the source of its mysterious ‘heartbeat’ remains unknown. This phenomenon was first documented in the early 1960s by geologist Jack Oliver, who suggested that the pulse might originate from somewhere in the southern or equatorial Atlantic Ocean. However, he lacked the sophisticated instruments needed to investigate further. “Jack didn’t have the resources in 1962 that we had in 2005 — he didn’t have digital seismometers, he was dealing with paper records,” Michael Ritzwoller, a seismologist at the University of Colorado, Boulder, told Discover Magazine. Since then scientists have spent a lot of time listening to this pulse and trying to solve the mystery.
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Lars Eivind Augland, associate professor in the Department of Geosciences at the University of Oslo, found the phenomenon of a 26-second pulse fascinating. “Yes, you may call it a kind of pulse. The Earth’s crust has regular tremors. They are so small that they do not pose a threat as real earthquakes can,” he told Yara International. Augland explained that every 26 seconds, the heartbeat of Earth is recorded by seismic station computers around the world. These blips are most noticeable in West Africa, North America, and Europe, he said. Geologists and seismologists have given varied explanations behind the occurrence of this phenomenon, including ocean waves, volcanoes, and fractures in sediments.
“Originally, the micro-quakes, or the pulse detected at intervals of 26 seconds, were explained by wave activity in the Gulf of Guinea in West Africa. Special depth conditions, the geometry of the ocean floor, and the coast have been pointed out as possible causes. Due to how the waves hit and create resonance on the seabed, they could, in turn, propagate as earthquake waves in the Earth’s crust,” explained Augland.
Representative Image Source: Pexels | Earano
In 2013, during the Seismological Society of America conference, a student named Garrett Euler also said the same thing, furthering the source location of the pulse to the region called “Bight of Bonny” in the Gulf of Guinea. He elaborated his hypothesis by adding that waves hitting and crashing against the coast might be the probable reason for this pulse. But this explanation was soon ruled out by most experts.
Apart from ocean waves, a second explanation behind this pulsation was believed to be “volcanoes.” The same year, Yingjie Xia from the Institute of Geodesy and Geophysics in Wuhan, suggested the cause was actually volcanoes, not waves. He explained this by saying that the island of São Tomé in the Bight of Bonny was close to the volcano.
Representative Image Source: Pexels | Mauro Ignacio Torres
After ruling out waves and volcanoes, Augland proposed a third explanation: sediment cracks. “A third explanation can be found in the latest study published in the renowned journal Earth and Planetary Science Letters, which states that fluid flowing through fractal fissure networks in sediments under the seafloor is the cause of the tremors,” Augland told Yara International, further specifying that none of the three explanations have any supporting evidence.
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Despite its puzzling nature, the 26-second pulse is not something unusual. According to BRIGHT SIDE’s YouTube video, Earth doesn’t only have a heartbeat but also a humming sound. Some people may notice it, and some may not, but this high-frequency buzzing sound called “The Hum” is prevalent throughout the planet. Like the mysterious ‘heartbeat,’ geologists have also tried to explain this “mysterious hum or buzz” but none has proved true to their satisfaction.

https://youtube.com/watch?v=ZBkOwyhq7Hg%3Fsi%3DKssLS49BY6VdPW8w

This article originally appeared last year.

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Cover Image Source: Orfield Laboratories – Photo credit: orfieldlabs.com

Exploration, Pubninja, Science

In Earth’s quietest room, even 45 minutes are unbearable for anyone

Standing in the room gives people creeps, making them feel as if they’re losing their spatial balance and orientation.

Neha B.

GOOD Staff

8/2/2025

Can silence drive us mad? This question arises from a unique room in Minneapolis, where visitors report eerie sensations and disorientation due to its profound silence. They often hear faint ringing in their ears, and so far, no one has lasted more than 45 minutes.
Holding the Guinness World Record for the quietest place on Earth, the anechoic test chamber at Orfield Laboratories has a background noise level of -24.9 decibels. The human audible range is from zero to 120 decibels, so a sound of negative decibels is inaudible by humans.
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An anechoic chamber, meaning “no echo,” achieves profound silence through its design. Fiberglass wedges coat the walls, floors, and ceilings, absorbing any internal sounds, while thick layers of brick and steel reinforce the soundproofing. This meticulous design guarantees complete isolation from external noise.

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The maximum someone has stayed inside this chamber is 45 minutes. The room is so quiet that a person inside it will hear their heartbeats, even the sounds of their organs, Steven Orfield, the lab’s founder, told Hearing Aid Know. “We challenge people to sit in the chamber in the dark – one person stayed in there for 45 minutes. When it’s quiet, ears will adapt. The quieter the room, the more things you hear,” he said, adding, “In the anechoic chamber, you become the sound.”
But the room isn’t designed for the sake of distressing or tormenting people. NASA regularly sends astronauts here to help them practice adaptability to the silence of space. Many people also visit the room to meditate, Orfield told CBS.
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Yet, for most people, the room offers an eerie and unsettling experience, as it can disrupt one’s sense of balance and orientation. “How you orient yourself is through sounds you hear when you walk. In the anechoic chamber, you don’t have any cues,” Orfield said. “You take away the perceptual cues that allow you to balance and maneuver. If you’re in there for half an hour, you have to be in a chair.”
Like Orfield Laboratories, the Microsoft headquarters in Redmond, Washington is also an anechoic place. It is the previous Guinness World Record holder for being the “quietest place on earth.” The room is designed in an onion-like structure that isolates it from the rest of the building and the outside world. Here too, people cannot stand the silence for too long, not more than 55 minutes to be precise.
Explaining to CNN, Hundraj Gopal at Microsoft said that in the real world, our ears are constantly subject to some level of sound, so there is always some air pressure present on the ear drums. But when someone enters the anechoic room, this air pressure zips away due to the total absence of sound reflections. In a room like this, there is no interference of noise.
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Ideally, silence is intended to pacify and soothe; however, its unsettling effect in these rooms is both uncanny and intriguing. For centuries, philosophers and poets have written that “silence is not empty,” and these anechoic rooms seem to provide evidence of this.
This article originally appeared last year.

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Stephen Hawking seemed to have answers for everything. – Photo credit: Stephen Hawking (Wikicommons)

Past Events, Pubninja, Science

Stephen Hawking’s simple response when asked if he believed in the existence of God

The renowned scientist shared his views on God in his book ‘Brief Answers to the Big Questions.’

GOOD Staff

7/27/2025

The existence of God has been a point of debate for centuries, examined through both religious beliefs and scientific inquiry. Theoretical physicist Stephen Hawking, known for his groundbreaking work in cosmology, addressed this question in his final book, Brief Answers to the Big Questions.
Although Hawking’s book was mostly completed before he passed, his family and academic colleagues helped finish it posthumously. In it, Hawking explored his thoughts on God’s existence, a topic he often faced as a scientist. Reflecting on his own disability, he remarked, “For centuries, it was believed that disabled people like me were living under a curse that was inflicted by God. Well, I suppose it’s possible that I’ve upset someone up there, but I prefer to think that everything can be explained another way, by the laws of nature.” His words reflect a belief in science as a way to understand the universe without needing to invoke divine forces.

Stephen Hawking Stephen Hawking (Wikicommons)

Image Source: Professor Stephen Hawking attends the gala screening of “Hawking” on the opening night of the Cambridge Film Festival held at Emmanuel College on September 19, 2013 in Cambridge, Cambridgeshire. (Photo by Karwai Tang/Getty Images)
He added that people like him, who believe in science, “believe that there are certain laws that are always obeyed. If you like, you can say the laws are the work of God, but that is more a definition of God than a proof of his existence.”
Hawking refused to acknowledge the existence of God with his most direct, personal answer as he outrightly said, “It’s my view that the simplest explanation is that there is no God. No one created the universe and no one directs our fate.”
The late astrophysicist had a prestigious career and made enormous contributions to science. He was commended for his work on the physics of black holes. Hawking proposed that black holes emit subatomic particles until they eventually explode. He also proposed the multiverse theory, which states that our universe is one of many parallel universes existing in a fractal-like multiverse, published in the Journal of High Energy Physics.
The genius scientist struggled with health complications throughout his adult life. At 21, he was diagnosed with Amyotrophic Lateral Sclerosis (ALS), which is a type of motor neuron disease. Despite the life-threatening disease, Hawking managed to live much of his life in a motorized wheelchair, communicating mostly with the assistance of a portable system mounted on its arms.
The renowned scientist passed away at the age of 76 on March 14, 2018, in his home. A year before that, he said he was thankful for his extended life. “I never expected to reach 75, so I feel very fortunate to be able to reflect on my legacy,” he said in an interview with BBC.

This article originally appeared last year.

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