The advancements of science over the past decade are pretty mind blowing. One fascinating area is the study of stem cells. Recent research into extracting the stem cells from the pulp of wisdom teeth is showing results that are extremely promising.
You probably know about the enamel of your tooth. Every toothpaste commercial talks about it. Beneath the enamel, at the center core of every tooth, is a pulp of loosely connected tissues. This paste of biological ingredients holds cells capable of behaving like neurons. Scientists have found this pulp fires off electrical signals that could be used to regrow spinal nerves and help patients to walk again.
Dentist shows x-ray to patient. Image via Canva – Phot by Polina Zimmerman
According to a study at the University of the Basque Country led by Dr. Gaskon Ibarretxe, taking the pulp from wisdom teeth created, “…neuronal-like cells that display functional excitability and thus evidence the potential of these easily accessible human stem cells for nerve tissue engineering.” Two important things to pull from that statement: stem cells can work and getting them is easy.
There are over 10 million wisdom teeth extractions performed every year in the United States. Once the teeth are extracted, they can be placed in a sterile vial, rushed to a lab, and have the pulp cells extracted and frozen within 24 hours. Studies are showing that the dental cells are some of the most adaptable and successfully explored of stem cells. With more research, they could play a major clinical role in spinal cord repair and beyond. Thus, being both readily attainable and usable, dental pulp stem cells make for a promising combination toward future advancements.
Thoughts from Redditors
A reddit thread talking about the “medical gold” to be found from extracting stem cells from teeth resulted in some interesting comments:
“Sounds like dentists should be paying us thousands for our wisdom teeth”
“Too bad I don’t have my wisdom teeth anymore”
“Why are we not funding this?”
“I have four! Still in my mouth…”
“Sooo… Can I sell them…?”
“They are literally wisdom teeth!”
“This is why the fairy pays good money for them. The business case was always a solid one.”
Research and studies on different disorders are also having success. In a study published through Passage Asia, the top five breakthroughs of 2024 are shared, with projected advancements for 2025. These breakthroughs include:
Cells used to treat epilepsy are having a positive impact on patients who were regularly having daily seizures. After treatment, the frequency of their seizures fell to about once a week.
People suffering Type 1 diabetes have had cells injected to begin the natural regulation of blood sugar levels. Some participants were able to stop insulin injections entirely.
There are cells implanted to repair the delicate tissues of the eye. Patients with severe age-related macular degeneration had improved vision after successful research into stem cell-derived retinal patches.
In other news, one clinical trial into stem cell treatment for heart disease, demonstrated that patients receiving injections after a heart attack experienced significant improvements to their over all heart function.
South Korea had a successful trial to repair severe cartilage damage. Patients with osteoarthritis showed significant improvement to joint function, overall pain reduction, and an increase of mobility after their injections.
A final study, according to The Guardian, might have found a cure for people suffering from sickle cell disease, a genetic blood disorder affecting the function and shape of red blood cells. This gene therapy takes the faulty genes in a patient’s own stem cells and edits them. The new blood cells are round and flexible, giving the person a better chance to live a longer, healthier life.
With so many advancements coming from the unlikeliest places, the future seems bright. And if you haven’t had your wisdom teeth pulled, the procedure may just change someone’s life one day.
Photo credit: Leigh Prather/Shutterstock.com – Dogs often react with great fear to July 4th celebrations. Border collies such as this dog are especially sensitive to loud noises.
The Fourth of July can be a miserable day for dogs. The fireworks make scaredy-cats out of many canines.
That’s because dogs, like humans, are hardwired to be afraid of sudden, loud noises. It is what keeps them safe. Some dogs, though, take that fear to the extreme with panting, howling, pacing, whining, hiding, trembling and even self-injury or escape. And, unlike humans, they don’t know that the fanfare on the Fourth is not a threat. Dogs hear the fireworks and process it as if their world is under siege.
How a dog responds to noises may be influenced by breed, with German shepherd dogs more likely to pace, while border collies or Australian cattle dogs are more likely to show their fear by hiding.
While we veterinarians don’t know exactly why some dogs are afraid of fireworks and others not, many dogs that react to one noise often react to others. Therefore, early intervention and treatment are essential in protecting the welfare of these terrified dogs. Here’s how you can protect your dog from fireworks.
Take your pet to the vet. If your dog is afraid of fireworks, the first step is to have your veterinarian evaluate him or her, especially if your dog’s noise sensitivity is relatively new. One 2018 study found a link between pain and noise sensitivities in older dogs, indicating that muscle tension or sudden movements in response to a loud noise may aggravate a tender area on the body and thus create an association between the loud noise and pain, causing fear of that particular noise to develop or escalate.
Create a “safe haven” in your home with a secure door or gate, preferably away from outside windows or doors. Close the blinds or curtains to reduce outside noises, and play some classical music to help reduce stress by creating a relaxing environment for your dog during the show. A white noise machine or box fan may also help reduce anxiety, along with a pheromone like Adaptil sprayed on bedding, a bandanna, a collar or from a diffuser plugged into the wall.
Consider noise-canceling headphones such as Mutt Muffs to muffle the sounds and further reduce noise sensitivities.
Find a food your pet will love. This could be cut pieces of boiled chicken or squeeze cheese. Sit with your pet and feed him with each boom. You can also use a long-lasting food-dispensing or puzzle toy to release food continuously during the show. This is to help your dog make a positive association with the noises for the future.
Consider anxiety wraps, fabric wraps that exert a gentle pressure on your dog’s body. These may help to lower heart rate and other clinical signs of fear and anxiety, operating on the belief that they swaddle a scared animal and thus calm its fears. These work best, however, in conjunction with a complete behavior treatment plan including medication or behavior modification, or both.
When it comes to comforting your dog, the jury is still out. It is difficult, however, to reinforce an emotional response with comfort. Therefore, it is OK to pet your dog when frightened by a noise event so long as the dog appears to be comforted and not more distressed by the attention.
Blooming flowers signal the beginning of spring, but for millions of people, they also signal the onset of the misery: allergy and asthma season. Itchy, watery eyes; sneezing, runny nose; cough and wheezing are triggered by an overreaction of the body to pollen.
Every spring, trees and grasses release billions of buoyant pollen granules into the air, using the wind to disperse across the countryside in an effort to reproduce. It’s all about survival; plants that release more pollen have the survival advantage.
As an adult and pediatric allergist-immunologist in the Midwest, the onset of spring signals my busy season treating hundreds of patients for their seasonal allergy and asthma symptoms. If you suffer through the season, know that you are not alone. Throughout history, pollen has taken the fun out of spring for many. In modern times, however, medical science has identified practices and treatments that help.
Older than the dinosaurs, as wide as the world
Fossilized specimens of pollen granules have been found predating dinosaurs and alongside Neanderthals.
And, sinus and asthma symptoms and treatments are documented throughout history and across the globe. People just didn’t know exactly how to treat the symptoms, or exactly what was causing them.
For example, over 5,000 years ago, the Chinese used the berries of the horse tail plant, ma huang (Ephedra distachya), to relieve congestion and decrease mucous production associated with “plant fever” – a condition affecting people during the fall.
In Egypt, the “Papyrus Ebers,” written around 1650 B.C., recommended over 20 treatments for cough or difficulty breathing, including honey, dates, juniper and beer.
Although Homer’s “Iliad” describes the loud noise of breathing in battle as “asthma,” Aretaeus of Cappadocia of the second century A.D. is credited with the first clinical description more consistent with modern understanding of this condition. He wrote of those who suffered that:
“They open the mouth since no house is sufficient for their respiration, they breathily standing, as if desiring to draw in all the air which they possibly can inhale… the neck swells with the inflation of the breath, the precordia (chest wall) retracted, the pulse becomes small and dense,” and if the symptoms persist, the patient “may produce suffocation after the form of epilepsy.”
Tobacco leaves were exported to Europe for experimentation in treating the symptoms of spring time coughing and sneezing. Jeep 2499/Shutterstock.com
By the time Columbus landed, indigenous populations in Central and South American were utilizing ipecacuanha, a root found in Brazil with expectorant and emetic properties and balsam, which is still used in some cold remedies today. Coca and tobacco leaves, used medicinally by the Incas, were later exported to Europe for additional experimentation for the treatment of rhinitis and asthma.
Aside from the “plant fever” described in China, the first written description of seasonal respiratory symptoms is credited to Rhazes, a Persian scholar, around 900 A.D. He described the nasal congestion that coincided with the blooming of roses, termed “rose fever.”
Symptoms noticed, but no cause identified
As scientific advancement was stifled during the Middle Ages, in large part due to the plague, it wasn’t until 900 years later, in 1819, that Dr. John Bostock published a description of his own seasonal allergies. But he didn’t know what was causing them.
Having suffered from “summer catarrh” since childhood, Bostock persisted in his study of the condition, despite an initial lackluster response from the medical community.
In the nine years between his first and second publications, he found only 28 additional cases consistent with his own seasonal allergy symptoms, which perhaps demonstrates the lower prevalence of the condition at the time. He noted that nobility and the privileged classes were more often afflicted by seasonal allergies. This was thought to be the consequence of wealth, culture and an indoor life.
Societal changes with their roots in the Industrial Revolution, including increased exposure to air pollution, less time spent outdoors, increased pollen counts and improved hygiene, all likely contributed to the increased prevalence of allergies that we continue to see today. They also helped form the hygiene hypothesis, which states that in part decreased exposure to particular bacteria and infections could be leading to the increase in allergic and autoimmune diseases.
The source of seasonal symptoms at the time was also thought to be caused by the smell of new hay. This led to the coining of the term “hay fever.”
Bostock instead suspected the recurring symptoms were triggered by the summer heat, since his symptoms improved when he spent the summer on the coast. It would later became common for nobility and aristocrats to spend allergy season in coastal or mountain resorts to avoid bothersome symptoms.
Identifying the true culprit
Through methodical study and self-experimentation, Dr. Charles Blackley identified that pollen was to blame for allergy symptoms. He collected, identified, and described various pollens and then determined their allergic properties by rubbing them into his eyes or scratching them on his skin. He then noted which ones resulted in redness and itching. This same technique is used in skin prick testing by allergists today.
Inspired by discoveries related to vaccination, Dr. Leonard Noon and John Freeman prepared doses of pollen extracts for injection in an effort to desensitize patients with allergic rhinitis in the early 1900s. This effective treatment, called allergy immunotherapy, also known as allergy shots, is still used today.
Antihistamines first became available in the 1940s, but they caused significant sedation. The formulations with fewer side effects that are used today have only been available since the 1980s.
Pollen counts likely to grow
Pollen on a street in Atlanta, March 31, 2019. Lynne Anderson, CC BY-SA
Though recognized by ancient civilizations, seasonal allergic rhinitis and allergic asthma have only increased in prevalence in recent history and are on the rise, now affecting 10 to 30 percent of the world’s population.
To keep you and your loved ones safe from pollen, close windows and change out of clothes exposed to pollen as soon as you come indoors. Monkey Business Images/Shutterstock.com
What can you do? Often, those who are allergic need a multifaceted approach.
Find out what allergens are causing your symptoms. Take note of when your symptoms start by making a note in a calendar or planner.
Minimize exposure to allergens. Track pollen counts. When pollen counts are high, keep the windows closed at home and in the car. After spending time outdoors, shower and change clothing to prevent ongoing exposure to pollen.
Take a pro-active approach to treating symptoms. Starting medications before symptoms develop can prevent symptoms from getting out of control. This can also decrease the amount of medication needed overall. Long acting non-sedating antihistamines are helpful for itching and sneezing. Nasal corticosteroid sprays are more helpful for stuffy noses.
Consider a visit to see a board certified allergist/immunologist. She or he can help you determine which particular pollens maybe the source of your symptoms.
Explore the role of immunotherapy with your doctor. Immunotherapy changes the immune response through administration of small regimented doses of allergens over time. This induces a state of tolerance, eventually helping people become less allergic over time.
While pollen season is coming, taking a multifaceted approach can provide much needed relief from the symptoms that have plagued humankind throughout the millennia.
Much like anything else, the cost of dental care has risen as need grows. A report from the American Dental Association found that, in 2024, dental spending grew by $7 billion from 2023. A young engineer is making a difference, though. He has helped put a smile back on the faces of folks in need by providing free dentures made with 3D printers.
Connor Gibson isn’t a dentist or even an expert on 3D printers. He’s a Tennessee community college student who wants to help people. While studying engineering at Walters State Community College, Gibson volunteered with Remote Area Medical (RAM). RAM is a nonprofit that provides mobile clinics offering free medical, vision, and dental care through volunteers.
An issue that bites
A common issue the clinics found was that many people needed dentures. The cost of dentures can be very pricey, ranging from $452 dollars to over $6,500 depending on the patient’s needs and their insurance coverage. Another issue was availability. Even if a patient could afford dentures, it could take weeks or even months before they could be delivered.
But Gibson had an idea. He thought that if he could 3D print pairs of dentures, it would save money and time. After all, having a 3D printer on-site would allow the dentures to be made within hours rather than weeks. A patient could get a free set of dentures the same day as their visit.
Great idea…but how?
There was a setback: Gibson had no experience in dentistry or 3D printing at all. In spite of his inexperience, Gibson used his engineering and design skills to teach himself how to use a 3D printer. He also got dental experts to teach him how to make dentures the old fashioned way. This way, he was sure to accurately recreate every detail via 3D printing. After taking an impression, Gibson was then able to design specific dentures per patient.
“Honestly, if you told me three years ago this is what I would be doing, I would have called you crazy,” Gibson said to CNN. “I made it my mission and studied up like I was doing a test, studying up on videos and documents — anything I could find on how to make a denture using this specific software and how to 3D print it.”
After Gibson successfully completed a pair of 3D-printed dentures for the first time, he knew it was something special. Seeing the tears of joy on the patient’s face was enough to confirm he was doing the right thing.
“That first delivery was really a huge eureka moment,” Gibson said. “To see that raw, human emotion and just know that I played a change in this person’s life… it’s very humbling, and I’m beyond blessed.”
Gibson has since been helping RAM develop more denture mobile clinics that can quickly develop dentures for patients who drop in.
How to find low-cost dental care near you
If you or someone you know needs low-cost to free dental care, there are options. In addition to Medicare, Medicaid, and CHIP, you can find local and state programs online. You can also dial 2-1-1 for information.
