When it comes to stopping the outbreak of a dangerous drug-resistant “superbug” bacteria, doctors often have to become detectives. They can treat each patient as they come in, but stopping the infection from spreading — that can be the key to saving even more lives.

Recently, a team at the University of Michigan and Rush University Medical Center used data from a real-world outbreak of a dangerous, drug-resistant superbug called CRKP to show that genetic testing can reveal how these superbugs are spreading, giving doctors a heads up on how to break the chain of infection and potentally stop an outbreak in its tracks.


The data from that CRKP outbreak provided researchers with the story of how the disease spread. In 2008, a man — who was incredibly sick and dying from a CRKP infection — was transferred to Rush University Medical Center in Chicago from a hospital in northern Indiana. Doctors there knew he wasn’t the first CRKP case in the Chicago area. Another case had cropped up just five months earlier.

Two cases of a dangerous superbug appearing in the same region had the doctors worried. A team headed by Mary Hayden, an infectious disease physician, began investigating. With a bit of legwork, they were able to find and map out the spread of the infection, watching how it hitched rides on dozens of different patients as they were transferred from hospital to hospital, nursing home to nursing home.

At the time, genetic analysis wasn’t sophisticated enough to really help Hayden track the chain of infection, but her team preserved samples from the patients anyway, hoping they could one day serve as time capsules for future investigations.

Now, they can.

The recent breakthrough involves whole genome sequencing. As bacteria grow and spread, they inevitably accumulate mutations in their genome, and by taking genetic samples from two different strains and comparing their unique mutations, scientists can tell if they’re related. It’s kind of like running a bacterial paternity test.

Hayden wanted to see if this kind of sequencing could have helped find the chain even faster during the 2008 outbreak.

To test her theory, she teamed up with Evan Snitkin’s genetics lab at the University of Michigan. Snitkin’s team tested each of Hayden’s samples in the order they were originally collected and without any prior information about each sample, essentially walking through the crisis beat-for-beat. As they did, they used the genome sequencing to build a kind of bacterial family tree.

When the two teams compared the new bacterial family tree with the results of Hayden’s 2008 investigation, they lined up nicely.

The technique won’t just duplicate conventional detective work, Hayden says. It could also help reveal nuances and insights into how a superbug is spreading, allowing doctors to move quickly to stop the chain of infection.

During the 2008 outbreak, for example, there were five patients, all at the same hospital, who had all caught CRKP. But doctors didn’t know how and when each patient picked up the bug. If one patient had carried it and spread it to all the others, for example, that’d mean the superbug was spreading within the hospital. On the other hand, if each patient had picked up the bug somewhere else and then came to the hospital, the source must be somewhere else.

Back then, the doctors had to work without knowing which scenario was true, but Hayden’s new genetic analysis showed that it had actually been a combination of both scenarios. Three of the patients contracted CRKP outside the hospital first, then two of them spread the bug to two other patients once they were hospitalized.

Had this technology been available at the time, doctors would have known as soon as they saw the test that they needed to do something to prevent transmission inside the hospital, such as isolating carriers and infected patients, as well as look for an outside source.

“The earlier we can intervene to contain an outbreak, the more likely it is that we can eradicate it,” Hayden explained in a press release.

Drug-resistant bacteria like CRKP have become a major medical problem in the United States. At least 2 million Americans catch one of these infections each year and more than 20,000 die from one.

The team’s process will still need to be tested in other settings, like nursing homes and with other diseases, says Hayden, but it should work with nonbacterial infections, such as those caused by viruses and fungi, and could provide a powerful complement to standard epidemiological detective work. The team’s work appeared in the journal Science Translational Medicine.

The team isn’t the only lab that has this kind of equipment and capability, and as such, they’re hoping their results can serve as a proof of concept for doctors and public health agencies like the CDC.

When outbreaks happen, doctors have to become detectives. Thanks to tools like this, the medical Moriarty that is superbug outbreaks may soon be easier than ever to defeat.

  • Health care sticker shock has become the norm, but talking to your doctor about costs can help you rein it in
    Photo credit: National Cancer Institute on Unsplash, CC BYA doctor at the National Cancer Institute talks with a patient.

    As health care costs rise, patients aren’t just shouldering higher bills. They’re bearing more and more responsibility for getting information.

    Americans are facing a health care affordability crunch on multiple fronts. In 2025, the Republican-controlled Congress approved a sweeping tax law that scaled back premium subsidies for Americans accessing care through the Affordable Care Act starting in 2026. As a result, millions on ACA plans now face much higher premiums, with many dropping out or expecting to drop out and risk going uninsured as premiums surge. By March 2026, about 1 in 10 people on ACA plans had dropped out, and that share is expected to rise.

    Meanwhile, high-deductible insurance plans have become more common, requiring patients to pay thousands of dollars before coverage fully kicks in. The rise of those plans, along with surging drug prices and the growing share of Americans who are under- or uninsured, means that medical debt remains a leading source of financial strain.

    Nearly half of U.S. adults now report difficulty affording health care. Together, these shifts are accelerating the “consumerization” of health care. Patients now have the ability to comparison shop, evaluate options and manage costs – but often without clear pricing. In this environment, knowing how to ask the right questions may be one of the most important tools patients have.

    We are professors who study how perceptions of health care costs shape patients’ decisions about their care. Our research examines how factors such as price-transparency regulations influence patient choices. Across our work, we consistently hear from patients about rising costs and how conversations about price with their providers too often never happen.

    Why speaking up about cost matters

    When one of us took our child to the doctor for pink eye, the pediatrician quickly sent a prescription for antibiotic drops to the pharmacy. At the pickup, the pharmacist dropped the news that the drops would cost more than US$300. A follow-up phone call to the doctor’s office, however, yielded important information: A generic version of the same medication offered the same treatment and the same results, but at a fraction of the price.

    That quick phone call saved her a lot of money. It also raised a broader question: Why don’t more people have these conversations about cost? In fact, one study shows that cost conversations occur in only about 30% of medical visits.

    These discussions aren’t just for medications. They can be crucial when a recommended procedure has multiple alternatives; when out-of-pocket costs might affect whether you follow through on care; or when a sudden medical bill could create financial strain. Speaking up about price can help patients stay healthier and avoid the all-too-common trade-off between medical care and household expenses.

    The study mentioned above also found that doctors and patients identified ways to reduce out-of-pocket costs – such as switching to a generic drug or adjusting the timing of care – in nearly half of those cases. Importantly, these conversations were typically brief and did not compromise the quality of care, the researchers found.

    Patients actually prefer doctors who bring up costs, other research has found. Still, most patients remain hesitant. While a majority say they want to discuss cost, only a minority actually do, often waiting until a bill arrives – often when it’s too late to consider alternatives. That’s why it’s important that consumers feel empowered to ask the right questions. Here are three that can help make care more affordable.

    A close-up of a person's hands, with pen in one, going over a complicated medical billing form.
    A patient works on a medical billing form. Mael Balland on Unsplash.CC BY

    Is there a generic or lower-cost alternative?

    One of the simplest ways to reduce drug costs is to ask whether a less expensive option is available. Brand-name medications can cost significantly more than generics, even when they are equally effective. One industry survey estimated that 90% of all prescriptions filled in 2024 were generic or biosimilar, but these accounted for only 12% of drug spending.

    In many cases, physicians can substitute a generic drug or recommend a similar treatment that achieves the same outcome at a lower price. And when no direct generic exists, there may be therapeutic alternatives worth considering. For example, if a brand-name eye drop or inhaler isn’t available in generic form, doctors can often prescribe a different medication in the same class that works just as well but costs far less. Research on physician–patient cost conversations shows that switching to lower-cost, clinically similar alternatives within the same drug class is a common strategy for reducing out-of-pocket spending without compromising care.

    Is there any financial assistance available?

    Some hospitals and large health systems have specific programs aimed at making care more affordable for lower-income patients. In many states, government programs address this same goal. These programs often offer discounts on care, but they can be complex to navigate and require significant paperwork. Many health care offices have staff who are knowledgeable about these programs and can help patients determine eligibility and sometimes even assist with applications, although the Trump administration has cut funding.

    Patients can often find these programs through hospital or health system websites, which typically include financial assistance or “charity care” pages outlining eligibility and how to apply. State Medicaid offices and insurance marketplaces are also key entry points for coverage and subsidy programs. Nonprofit organizations and patient advocacy groups may also offer or list assistance tailored to specific conditions or medications.

    It’s also important to remember that for prescription medications, what you’re quoted isn’t always the final price. Many medications come with options to reduce costs, including manufacturer coupons, copay assistance programs and patient assistance programs. Doctors’ offices and pharmacists may also know practical ways to save money, such as using a different pharmacy, switching to mail order or adjusting how a prescription is written. Asking about these options can uncover savings that aren’t immediately obvious.

    What will this cost me, and are there other options?

    Health care pricing is often opaque, and costs can vary widely depending on where and how care is delivered. Asking up front about your expected out-of-pocket cost can help you avoid surprises later.

    This question also opens the door to alternatives. For example, patients may be able to choose a lower-cost imaging center, opt for outpatient rather than hospital-based care, or delay nonurgent services until insurance coverage improves.

    Speaking up is part of taking care of your health

    Health care decisions shouldn’t feel like a choice between your well-being and your wallet. A brief, honest conversation about cost can lead to more affordable and more sustainable care.

    Physicians can’t address financial concerns they don’t hear about, and most want to help their patients access care they can realistically follow through on. As costs continue to shift toward the patient’s burden, asking these questions isn’t just helpful – it’s essential.

    The next time you’re handed a prescription or a referral, remember: One simple question about price could make all the difference.

    This article originally appeared on The Conversation. You can read it here.

  • Snoozing in bed is actually bad for you, but here’s how to get out of bed comfortably
    Photo credit: bruce mars via UnsplashA woman sleeping on her pillow.
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    Snoozing in bed is actually bad for you, but here’s how to get out of bed comfortably

    When you disrupt NREM sleep, you disrupt the body’s replenishing capabilities.

    We all know that moment when the alarm goes off in the morning and you start thinking about who you wouldn’t murder for another five minutes (another 10 minutes?!) of sleep. You hit the snooze button, and your eyes drift closed again, only to be thrown open as the alarm sounds one more time. While those extra few moments of sleep might feel wonderful at the time, they’re never as good as simply waking up and staying up and can even cause more harm than good.

    “The name for the uncomfortable feeling on awakening is ‘sleep inertia,’” writes Dr. Keith Roach in The Detroit News. Sleep inertia is that feeling of zombie-like grogginess you get when you wake up again shortly after being up once before, like when you hit the snooze button or take a nap. According to Sleep Foundation, it can also include “disorientation, drowsiness, and cognitive impairment that immediately follows waking.” Though going back to sleep might feel nice for a short time, you’d actually be better off for the rest of the day by just getting out of bed, especially if you wake up naturally feeling well-rested, Roach continues. 

    While there’s not an explicit understanding of why sleep inertia happens, according to the Sleep Foundation, it could be related to a disturbance of NREM sleep, non-rapid eye movement sleep, which is “an essential part of the sleep cycle,” that’s important because it’s when the body takes time to repair itself. When you disrupt NREM sleep, then, you disrupt the body’s replenishing capabilities. This brings on that groggy feeling, because 10 minutes isn’t just 10 minutes; your body’s actually resetting itself for anywhere from 30 minutes to some four hours. What you end up doing, according to Dr. Sam Wagg of Fix Medical Group in San Diego, is trading 10 minutes for an even longer period of time to recover, and it just isn’t worth it. “Pressing snooze can make sleep inertia worse because of the repeated forced awakenings,” says psychiatrist Dr. Tracey Marks. “Our brains don’t like waking up and going back to sleep and waking up again in a short time period.”

    Luckily, with modern advents, you don’t have to do this on your own. As Dr. Marks shares, there are several ways to make waking up easier. One of them is by choosing relaxing sounds to wake up to, and allowing them to slowly increase volume while the alarm goes off. Another is choosing a regular time to rise, weekends included. “This keeps your body clock in sync,” she says. You can also choose to wake up to natural light or invest in a sunrise alarm clock. Last but not least, Dr. Marks says, you actually have to get up and “move around so that your body can know it’s time to start the day.”

    According to the Sleep Foundation, you can also limit caffeine, make sure the room is cool, and reduce the use of substances like cigarettes and alcohol. Another useful warrior against sleep inertia is bedding that enhances your sleeping experience. This can include “natural, breathable fibers like wool, down, cotton, linen and silk…[that] feel soft and comfortable for your body,” Apartment Therapy shares.

    And while a cool, cozy bed nestled in soft light and music sounds like something you may never want to leave, it will actually help you get out of bed feeling that much more rested and ready to take on the day, leaving sleep inertia in the dust.

    This article originally appeared last year. It has been updated.

  • The good life requires two things, self‑knowledge and friends – you can’t have one without the other
    Photo credit: Stephen Simpson/Stone via Getty ImagesFriends can see and know you in ways that you yourself never can.
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    The good life requires two things, self‑knowledge and friends – you can’t have one without the other

    A global study links nature connection with resilience, mindfulness and life satisfaction.

    Friends can help us with all kinds of things in life. How could I forget moving that piano for friends in Chicago? Fortunately, none of us ended up in the ER.

    One of the most important things friends do, though, might seem surprising: They help us get to know ourselves.

    Both in their 50s, Cindy and Ann had been friends since the second grade. Year after year, they never missed a birthday. Cindy would give Ann gourmet popcorn or maybe a sweatshirt from her alma mater, while Ann would give Cindy a special book on a topic that interested her, or maybe an old batch of family recipes. At one point, it dawned on Cindy just how thoughtful Ann’s gifts were. It wasn’t about the cost. “She really thinks about my life and what I’m doing,” Cindy said. “It’s amazing. Ann is just really thoughtful.”

    Cindy had always imagined herself as a thoughtful person, too. But in comparing the kinds of gifts they sent to each other, she realized that she was not thinking about Ann in the way that Ann was thinking about her. And so began her deliberate process of becoming more thoughtful – as a result of the self-insight she had gained from her friendship with Ann.

    As a philosopher and philosophical counselor, I’ve noticed the pronounced connection between friendship and self-knowledge in my counseling practice. Cindy and Ann are one example among many. I’ve come to the conclusion that to really know yourself, it’s necessary to have good friends.

    The link between self-knowledge and friendship was key for Aristotle, too, more than 2,000 years ago. “Eudaimonia” – roughly translated as living well, or happiness – often remains elusive, yet Aristotle believed it didn’t have to be. Eudaimonia is largely within people’s control, he said, so long as they aim at the right targets.

    Two of those targets are knowing yourself and having good friends. The two are tied together – you can’t develop self-knowledge in a vacuum. Happiness, for Aristotle, can never be a solitary pursuit.

    Knowing – and befriending – yourself

    Humans have a highly developed capacity to think about their thinking. This is possible because of a split in human consciousness: There is consciousness, and there is consciousness of consciousness – what is known as reflection or metacognition. Metacognition allows us to step back and note our thoughts and feelings, analyzing them almost as if they belonged to someone else.

    This split makes reason, self-knowledge and morality possible. We can deliberate about our thoughts, feelings and potential actions.

    A faded painting shows two bearded men in robes, one of whom has gray hair, walking and gesturing side by side.
    A detail from ‘The School of Athens,’ by Raphael, shows Plato and Aristotle, his student, deep in discussion. Apostolic Palace/Web Gallery of Art via Wikimedia Commons

    Self-knowledge isn’t the same as being intellectual or even intelligent. Instead, it’s about using self-awareness and reason to develop character.

    In Aristotle’s view, character arises from developing habits that lead to intellectual and moral virtue, so that personal integrity is possible. This, in turn, builds self-trust and self-respect, as you learn to rely on yourself to do what is right – what Aristotle called “enkratēs,” or continence.

    In other words, self-knowledge is developing a good relationship with yourself. In your own internal dialogue, you become another trusted friend to yourself, based on what you’ve seen in your friendships: virtues like generosity, courage, truthfulness and prudence. Self-knowledge and moral development are tied together and realized in community, as underscored by Aristotle scholar Joseph Owens.

    Friendship based on character

    Aristotle recognized three types of friendship. Some are based on utility, like a study-group friend. Others are based on pleasure, such as friends in an antique car club.

    The third and highest form of friendship, which can last a lifetime, is based on virtue, or “arete.”

    In these situations, Aristotle wrote, a friend becomes “another self.” These friendships are based on mutual goodwill and love for the other person’s character; they are not fundamentally transactional. Instead, they are anchored in care and concern for the other.

    Such friendships are few, but foster self-knowledge. As philosopher Mavis Biss emphasizes, a good friend has a perspective on you that you yourself do not. You can step back and analyze your desires, thoughts and feelings, but you can never actually observe yourself.

    That means self-knowledge always has a social dimension. True friends enhance each other’s insight and capacity for virtue. As you get to know your friend, you get to know yourself – and are challenged to become a better version of yourself.

    “To perceive and to know a friend, therefore, is necessarily in a manner to perceive and in a manner to know oneself,” Aristotle wrote in the “Eudemian Ethics.” The friend is a mirror that helps refine our thinking, perception and moral understanding.

    Two women with gray hair and glasses sit inside a tent, looking out at a pond, as they smile and chat.
    A trusted and respected friend shares ideas, gives fresh perspective and magnifies life’s pleasures. Johner Images/Johner Images Royalty-Free via Getty Images

    Aiming at the good life

    In the end, what makes eudaimonia – the good life – possible? For Aristotle, it’s using reason to become our best selves. Knowledge and self-knowledge are the most desirable of all things, Aristotle argued: “One always desires to live because one always desires to know, and because one wishes to be oneself the object known.”

    And there’s no way to get there without good friendsA trusted and respected friend shares perceptions, enhances self-knowledge and magnifies life’s pleasures.

    The desire to know and be known is part of the quest for happiness. Knowledge of self, others and everything else is interconnected. For Aristotle, relationships are a portal into the realms of the vast and mysterious universe.

    This article originally appeared on The Conversation. You can read it here.

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