Media outlets love to compile lists of impressive people under a certain age. They laud the accomplishments of fresh-faced entrepreneurs, innovators, influencers, etc., making the rest of us ooh and ahh wonder how they got so far so young.While it’s great to give credit where it’s due, such early-life success lists can make folks over a certain age unnecessarily question where we went wrong in our youth—as if dreams can’t come true and successes can’t be had past age 30.
Weary of lists celebrating youngsters, television writer and producer Melissa Hunter sent out a tweet requesting a new kind of list for 2020. “Instead of 30 Under 3 or NextGen lists,” she wrote, “please profile middle-aged people who just got their big breaks. I want to read about a mother of 2 who published her first novel, a director who released their first studio feature at 47, THAT’S THE LIST WE WANT.”
u201cAt the end of 2020, instead of 30 Under 30 and NextGen lists, please profile middle-aged people who just got their big breaks. I want to read about a mother of 2 who published her first novel, a director who released their first studio feature at 47, THAT’S THE LIST WE WANT.u201d
The Twitterverse responded with a resounding “YAAASSS.” Story after story of folks finding success in their 40s, 50s and beyond began pouring in. If you worry that you’re not far enough along in your 20s or 30s, or think it’s too late for you to follow your passion in the autumn of your life, take a look at these examples of people crushing it in their mid-to-late adulthood.
Take this mother of four teens who released her first full-length book at 45 and started law school this year at age 47.
u201c@melissaFTW @becauseivy I am a mother of four, I released my first full-length book at 45, and started law school this yearu2014at 47u2014with four teenagers in the house. Some of us are late bloomers, but wow, when we figure it out…ud83dudd25u201d
Or the woman who published two books in her late 50s and is revising book #3 at age 60. Oh, she also started running at age 45.
u201c@melissaFTW My first book was published when I was 57, second, at 58, and now at age 60, working on revisions for book #3. Also, I didn’t start running until after I turned 45 (averaged 1,000 miles/year for several years.) #nevertoold #nevertoolate #nevergiveup #dreambig #workhardu201d
Yet another mother of two teens finished her PhD at 41 and got a tenure-track position at age 47. She’s also working on a book on Indigenous Early Childhood.
u201c@melissaFTW @A_Story_of_A Finished my PhD at 41 with two teens as an Indigenous woman in public health. Finally got a tenure-track position after gig work in 2018 at age of 47. I’m an Associate Director &Assistant Prof with an academic book in the works on Indigenous Early Childhoodu201d
How about this woman who hadn’t taken a math class for 40 years? She aced her statistics classes and will graduate with a perfect GPA after she turns 60. “Lots of life to live!” she says.
u201c@melissaFTW @whoisgarylee Workings on my doctorate. I had not taken a math class for 40 years but aced statistics and advance statistics with Au2019s. I will graduate with a 4.0 at the ripe age of 60+. The dissertation is all I have left. Lots of life to live!u201d
Another mom (are we seeing a theme here?) discovered a passion for interior design and won a national TV design challenge in her late 40s. Now, at 60, she has a successful design career and contributes to radio and magazines.
u201c@melissaFTW I was a stay at home Mum for years. In my late 40u2019s I discovered a passion for interior design &won a national TV design show challenge. I now have incredible clients &projects, contribute to national radio, and write a popular magazine column. Iu2019m 60 this year, and on fire!u201d
Of course, we also know there are fabulously successful folks who got a “late” start in Hollywood, including the incomparable Ava DuVernay, “who left her job at age 40 to focus on filmmaking and then became the first Black woman to make over $100 million at the box office.”
u201c@melissaFTW And let it also include the record-breaking film director @ava who left her job at age 40 to focus on filmmaking and then became the first black woman to make over $100 million at the box officeu201d
As one man pointed out, “The idea that you’ve got five years between 20 and 30 to do everything you’re ever going to do is ridiculous.” Hunter agreed, writing, “The advice is always that it’s a marathon, not a race and I wanna read about the people who finished that marathon!!”
u201c@rothschildmd congrats! and agreed. the advice is always that it’s a marathon, not a race, and i wanna read about the people who finished that marathon!!u201d
So many stories of people publishing their first books, landing their ideal jobs, or discovering a passion later in life just kept coming, and person after person shared how inspiring and motivating they were.
Of course, not everyone has lofty career goals. If these stories aren’t quite hitting the mark for you, check out this woman’s contribution to the conversation. She’s “just a regular human,” she says, but she went to Zimbabwe and volunteered at a wildlife refuge at age 47. “Life doesn’t just peter out after 30,” she wrote. “My friend Elsa is 96 and went on an archaeological dig at 75. I want to be like her.”
Don’t we all.
u201c@melissaFTW I didnu2019t publish anything, Iu2019m just a regular human, but I went to Zimbabwe and volunteered at a wildlife refuge at 47, saw Victoria Falls. Life doesnu2019t just peter out after 30. My friend Elsa is 96 and went on an archaeological dig at 75. I want to be like her.u201d
Age really is just a number, and there’s nothing magical about “making it” in your younger years. Let’s be sure to celebrate people living their best lives and making dreams come true at any and every age.
Using an in-home HEPA purifier for one month spurs a small but significant improvement in brain function in adults age 40 and older. That’s the result of a new study we co-authored in the journal Scientific Reports.
We analyzed data from a study of 119 people ages 30 to 74 living in Somerville, Massachusetts. Somerville sits along Interstate 93 and Route 28, two major highways, resulting in relatively high levels of traffic-related air pollution. This makes it an especially good location for testing the health effects of air purifiers.
We randomly assigned participants to one of two groups. One used a HEPA air purifier for one month and then a sham air purifier – which looked and acted like the real thing but did not contain the air-cleaning filter – for one month, with a month-long break in between. The second group used the real and sham purifiers in reverse order.
After each month, participants took a test that measured different aspects of their mental capacity. The test probed people’s visual memory and motor speed skills by measuring how quickly they could draw lines between sequential numbers, and it tested executive function and mental flexibility by asking them to draw lines between alternating sequential numbers and letters.
We found that participants 40 years and older – about 42% of our sample – on average completed the section testing for mental flexibility and executive function 12% faster after using the HEPA purifier than after using the sham purifier. That was true even when we accounted for factors like differences in the amount of time participants spent indoors, with either filter, as well as how stressful they found the test.
This improvement may seem small, but it is similar to the cognitive benefits that people experience from increasing their daily exercise. While you may not experience a sudden increase in clarity from a 12% boost, preventing cognitive decline is vital for long-term well-being. Even small decreases in cognitive functioning may be associated with a higher risk of death.
Why it matters
Air pollution can negatively affect mental function after just a few hours of exposure. Studies show that air purifiers are effective at reducing particulates, but it’s unclear whether these reductions can prevent cognitive harm from ongoing pollution sources like traffic. Research has been especially lacking in people living near major sources of air pollution, such as highways.
Our study shows that HEPA air purifiers may offer meaningful health benefits under these circumstances.
What still isn’t known
Research shows that air pollution begins to affect cognitive function especially strongly around age 40. These effects may become increasingly prominent as people age.
HEPA air purifiers may therefore be especially beneficial for older adults. Our study did not explore this possibility, as fewer than 10 of our 119 participants were over the age of 60.
Also, our participants only used a HEPA air purifier for one month. It’s possible that longer durations of air purification may sustain or even increase the improvement in cognitive function we observed in our study.
We plan to study whether reducing particulate matter by using air purifiers is indeed protecting the brain’s white matter, and whether it could reverse some cognitive decline. We will explore that possibility by studying how levels of molecules called metabolites, which cells produce as they do their jobs, change in response to breathing polluted air and air cleaned by a HEPA filter.
The first time the placebo effect really got under my skin was when I read that roughly one-third of people with irritable bowel syndrome improve on placebo treatments alone. Usually this statistic is presented as a fascinating quirk of medicine. My reaction was anger.
Humanity possesses an extremely effective treatment, with essentially zero side effects – and patients need someone else’s permission to use it.
The placebo effect refers to the improvements in symptoms that patients experience after they’re given an inert treatment like a sugar pill. Driven by expectation, context and social cues rather than pharmacology, the placebo effect is often dismissed as all in the mind. But decades of research have shown it is anything but imaginary.
Placebo treatments can trigger measurable changes in the brain, immune system and hormone function. In studies on pain, placebos cause the brain to release endorphins, the body’s natural opioids. In Parkinson’s disease, placebo injections increase dopamine activity in the brain. The placebo effect isn’t magic. It’s biology.
Having spent nearly a quarter-century teachingevolutionary medicine, I’ve come to see placebos not as curiosities of clinical trials but as windows into how human biology responds to social signals. And it’s that relationship that is exactly what makes the placebo effect unsettling.
When testing a new drug, scientists compare its effects to what patients experience on a placebo treatment like sugar pills, saline injections or sham surgery. If the drug doesn’t outperform the placebo, it rarely reaches the public. Placebo responses are common and powerful enough to rival active treatments.
Even surgery isn’t immune to the placebo effect. In several well-documented studies of knee procedures, patients who received sham operations – incisions without the full surgical repair – improved almost as much as those who received the real procedure.
Clearly something real is happening inside the body. But the strangest part of the placebo effect is not that it works. It’s what makes it work.
The prescription of belief
Placebo treatments tend to be more effective when delivered by credible authorities. Pills work better when prescribed by doctors wearing white coats. Expensive pills outperform cheap ones. Injections produce stronger responses than tablets.
Some researchers have even removed the deception from placebo experiments entirely. In open-label placebo studies, patients are directly told they are receiving a placebo; and yet many still report significant improvement.
But look more closely at how these studies are run. Patients are not simply handed a sugar pill and sent home. They receive an explanation from a clinician, in a medical setting, within a structured ritual of care: a context that may be doing much of the biological work.
Even when the deception disappears, the social scaffolding remains. The permission to heal is still being granted by someone else.
The placebo effect extends beyond the patient
The placebo effect is often framed as something happening inside an individual. But it does not operate in isolation.
Consider what happens in veterinary medicine. Dogs and cats cannot believe a treatment they’re given will work; they have no concept of receiving medication. Yet when owners and vets believe an animal is being treated, they consistently report improvements in pain and mobility that medical tests do not confirm.
In one study of dogs with osteoarthritis, owners reported improvement roughly 57% of the time for animals receiving only a placebo.
The animals themselves may not have improved. But the humans caring for them perceived they had. The healing signal, it turns out, travels through the humans in the room.
When healing makes things worse
There have been times when going to the doctor made you less likely to survive. In the 19th century, mainstream medicine was built on bloodletting, purging and doses of mercury and arsenic – treatments that killed as often as they cured.
Homeopathy emerged in the late 18th century precisely in this context. Its founder, Samuel Hahnemann, was a physician horrified by the harm the conventional medicine of his time was causing. His highly diluted versions of contemporary remedies did nothing pharmacologically. But they also did not kill people, which put them decisively ahead of the competition.
Homeopathic patients not only survived but also reported dramatic recoveries from chronic ailments and acute infections alike. During the cholera epidemics of the mid-1800s, patients at homeopathic hospitals had lower death rates than those receiving standard care. Why was that?
The standard cholera treatment of the era was aggressive and exhausting; for a disease that already caused massive fluid loss, doctors often prescribed further bloodletting, along with toxic purgatives such as calomel – a form of mercury – to “flush” the system. In contrast, homeopathic care involved extreme dilutions of substances in water or alcohol, effectively providing hydration and a calm, structured environment without the physiological assault.
Death rates were lower not because homeopathy worked but because the placebo effect – combined with not poisoning patients – was more effective than the medicine of the day.
Healing is not free
The body needs resources to heal from injury and disease. Activating systems such as immune responses, tissue repair and inflammation at the wrong time can be dangerous.
Some researchers have proposed that placebo responses reflect a kind of biological health governor: a system that regulates when the body invests heavily in recovery. Cues from trusted individuals may be exactly the signal the body waits for before committing resources to recovery. A caregiver’s reassurance, a physician’s authority and the rituals of medicine may tell the body that conditions are finally stable enough to devote energy to healing.
If that interpretation is correct, the placebo effect is not a trick of the mind. It is an ancient biological system responding to social information.
Body under stress
The placebo effect resembles another system people struggle with today: the stress response.
Stress evolved to keep you alive in the face of acute danger – predators, famine, immediate physical threat. These days, this useful piece of biological engineering might fire when someone hasn’t replied to your email. The system that once saved people’s lives now makes many miserable over things that would have been unimaginable to their ancestors.
You can talk back to the stress response, consciously reappraising the threat – in other words, reframing a looming deadline not as a catastrophe but as a manageable challenge – to help quiet it. But notice what you cannot do: You cannot simply decide to activate your placebo response. You cannot will yourself to release pain-relieving endorphins by believing hard enough in a sugar pill. For that, you still need the ritual, the white coat, the authority figure. You need someone else.
The stress response, misfiring as it is, remains yours. The placebo response has been outsourced: not because it wasn’t always social, but because even now, people still can’t seem to access it on their own.
The uncomfortable implication
The placebo effect is not a trick of the mind. It is a feature of human biology that people have largely surrendered to whoever performs authority most convincingly.
If belief can activate biological healing pathways, belief can also be manipulated. Charismatic figures, elaborate medical rituals and expensive treatments may produce real improvement in symptoms even when the underlying treatment is physiologically inert. That is how wellness culture works. It leverages the same social scaffolding of care to trigger the body’s internal pharmacy, regardless of whether the treatment itself does anything.
The placebo effect is often celebrated as proof that the mind can heal the body. But I believe that may not be its most interesting lesson. It also reveals that human physiology evolved to take its cues from other people. Your brain, immune system and pain response are not isolated machines. They are deeply intertwined with social signals, expectations and trust.
In a world filled with doctors, advertisements, wellness influencers and elaborate medical rituals, that insight is both fascinating and profoundly maddening. People are walking around with one of the most powerful healing systems ever documented locked inside them, and they can reliably access it only when someone in a position of authority gives them permission.
She was right to be touched. He had actually thought about what she would like. She’s health-conscious, so he tailored the meal to her preferences. As they sat down he proudly explained what he’d made and why.
It was designed, he told her, for her prostate health.
A visibly confused woman tries to think. Photo credit: Canva
Sedlak asked him if he meant his prostate health.
He confidently said no. He meant hers.
Sedlak, an actress and filmmaker with 145K Instagram followers, shared the moment in a video posted on November 22, 2025 under her handle @alexandrasedlak. She described the progression from delight to confusion with great precision. “I am dating a dummy,” she concluded in the video. “But he is my little dummy, and no one can take that away from me ever.”
For reference: the prostate is a gland in the male reproductive system, located below the bladder. Women do not have one. A study published in PMC found that men’s knowledge of gynecologic anatomy tends to be significantly lower than women’s, which at least provides some scientific context for this particular gap running in the other direction.
The comments were predictably delighted. One person suggested she invite him over and cook a meal focused on his ovulation health, then casually ask what part of his cycle he’s in. Another compared him to a golden retriever who should be given head scratches and told he’s a good boy.
He is very caring. He cooked her a whole meal. The organ was wrong but the intention was right.
For more relationship-based content, follow @alexandrasedlak on Instagram.
