Yesterday afternoon, President Obama visited a local Boys & Girls Club where he hand-delivered cookies in the shape of Bo, the first dog.He also read aloud from The Polar Express and reminded a rapt audience of 27 children that Christmastime is about more than just gift-getting.While the coverage of the holiday feel-good story was decent, none better captured the mood than pool reporter Margaret Talev, who covers the White House for McClatchy Newspapers.Below, her dispatch.Upon arrival, President Obama playfully asks kids, “Have you guys been good?” YES! they answer in unison, sing-songy. “Do you think you deserve cookies?” YES! “You sure, now?” YES!POTUS was not wearing a Santa costume; just a suit and tie as earlier in the day.Several of the kids already knew “Polar Express” in book or movie format. POTUS’ inflection and ad-libbing suggested that of an experienced bedtime-story-reading parent. (He even got into character during one passage where Santa says, “Ho, ho, ho” though POTUS’ imitation sounded more like “Huh, huh, huh.”) POTUS did not flinch when a sign fell off the wall and landed on the floor a couple feet behind him.Later he told the kids he and his older daughter, Malia, had read all the “Harry Potter” books together.He asked the kids what they wanted for Christmas but seemed surprised by their expensive and high-tech tastes, including iPods, cell phones and video games.“Whatever happened to, like, asking for a bike?” POTUS asked. “Everbody has a bike,” one informed him and others agreed.In another exchange, he asked a kid who wants a cell phone, “Who you gonna call?” Kid: “Everyone.” POTUS: “Like who?”Later, one kid says Christmas celebrates “the birth of Baby Jesus” and POTUS said it also represents “the possibility of peace” and people treating one another respectfully. “It’s not just about getting a gift.”They talked about the Three Wise Men, and how despite their status they came to a manger to pay respects to a baby.POTUS tells kids to be kind to others and that “what’s important is the kind of spirit you have.”Your pooler would note for those of you who haven’t seen the video yet that the children were all over POTUS, tugging on his arms, making small talk, trying to get him to stay. “I gotta leave now, I gotta go do some work,” he apologized to one girl.The kids also were very respectful, saying “thank you” and even “thank you, Mr. President” as he stooped over them to pass around the cookies. “Go on and take a bite!” he prodded. He also did his standard speech on study your reading and math and you might be president.He seemed to be enjoying himself very much.At the end, Niko Letterbough, 7, gave him T-shirts for his daughters on behalf of the group, and asked if he’d come back and if he’d play him at Foosball.“You know, I hate getting beat,” POTUS told him.”“I’ll let ya win,” Niko said, and they fist-bumped. POTUS: “That’s what I’m talking about.”No opportunity for questions.Photo via
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New Russian research suggests that the human lifespan could be up to 156 years
Humans can live much longer if certain barriers are addressed.
According to the Guinness Book of World Records, the oldest person lived to the ripe age of 122 years old. Such a lifespan is an incredible feat, but what if the average person could beat that record by 34 years? Recent research done in Russia has led scientists to believe that the average human lifespan could be up to 156 years.
The researchers at Skoltech Biomed Technologies Center developed a mathematical model that allowed them to “switch on” a variety of aging mechanisms. This allowed them to calculate a human’s lifespan where mortality risk never increased with age. After experimenting with different scenarios and conditions, they found the biggest barriers to longevity were caused by non-renewable tissues and somatic mutations.
What are these barriers against longer life?
Somatic mutations are DNA changes within a cell. They accumulate over time during a human’s life and cannot be reversed with any existing therapy. These DNA errors that pile up in our cells contribute to the aging process.
Many human organs like the liver and skin continually replace cells and regrow damaged portions of themselves. However, there are two organs that can’t do this: the brain and the heart. Brain tissue (neurons) and heart tissue (cardiomyocytes) cannot regenerate. This proves to be the most prominent biological limit that shortens our lifespans. This explains why issues like dementia and heart disease are prominent causes of death and morbidity later in life. Since those organs’ tissues don’t replace damaged cells, they’re prone to irrevocably decline over time.
“The key finding of the study is the discovery of substantial differences between tissue types. Neurons and cardiomyocytes, which lack the ability to divide, turned out to be the main limiting factors: when all other causes of aging are eliminated, somatic mutations alone reduce the theoretical median lifespan from 1,759 years (for a hypothetical non-aging human organism) to 156 years,” said Evgeny Efimov, a research intern at the Skoltech Biomed Technologies Center, researcher at AIRI, and one of the key authors of the study.
This suggests that somatic mutations and DNA damage is what ultimately prevents humans from living indefinitely, even if our brains and hearts regenerated cells like other organs.
So what’s next?
Now knowing these biological limitations, the researchers hope to study other areas of aging impacting the human lifespan that could plausibly be reversed. This includes mitochondrial dysfunction, telomere shortening, epigenetic drift, and loss of proteostasis.
The hope is to have a clearer priority list of issues for future therapies to tackle. This is not just to possibly extend life, but to improve lives in general. By developing a fully comprehensive theory of aging, Skoltech hopes to pinpoint which aspects of aging are within our scope to address. After all, thoroughly studying each puzzle piece that makes up human life gives us a better understanding of the whole.
Of course, other impactful factors in a person’s lifespan can be addressed today. As most know, things like diet, sleep, and exercise are among them. A person’s living environment can also negatively impact their lifespan if it doesn’t have clean air, access to clean water, and so on.
For now, the best method for living long is to follow instructions from your physician. Whether you make it to 156 years or not, living well is best for whatever time you’re given.
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