The holidays have a way of drawing even the most secular people toward houses of worship. So whether religion is part of your everyday life or Christmas Eve is the last time anyone will spot you near an altar until Easter, it’s likely you’ll encounter someone undergoing a spiritual experience in the coming days. Ask someone what it’s like to “feel the spirit,” and they’ll probably describe it as mysterious, even unknowable. Yet, thanks to new research, neuroscientists can tell us exactly what’s happening in the brain at that moment.


According to recent findings published in Social Neuroscience as part of an ongoing study called the Religious Brain Project, researchers have found evidence that when a brain is “on God,” its reward circuits are activated—just as they are when listening to music, having sex, getting high, or falling in love.

[quote position=”left” is_quote=”true”]I have had spiritual experiences where I think they must be like getting high, but without the hangover.[/quote]

Michael Ferguson, a postdoctoral associate in the department of Human Development at Cornell University who does not practice any religion, served as the lead researcher for the study, which he says he undertook in an attempt “to understand the nature of the exquisitely powerful experiences” of the Mormon faith of his upbringing. Together with colleagues at the University of Utah, Ferguson drew on the large Mormon population in the area to initiate the first leg of this multireligion project, inviting 17 practicing Mormon participants to engage in religious activities typical of Mormon worship while inside a functional magnetic resonance imaging scanner.

These activities included quiet personal prayer, reading scripture from The Book of Mormon, and watching videos of religious leaders preaching. Participants were asked to report when they were—as noted above—feeling the spirit. “We used the cultural lexicon rather than trying to generate some type of awkward scientific language for the questions,” Ferguson says.

To Ferguson’s delight, when participants reported religious connection, their brain’s “dopaminergic reward circuitry” lit up—the same part activated by drugs or gambling. The structure is known as the nucleus accumbens, connected to the medial prefrontal cortex, which is associated with focused attention. These results might explain why people’s experiences of religious or spiritual experience often seem to have an element of ecstasy or euphoria, one akin to more illicit behaviors.

Lissa Provost, a Pentecostal Christian from California who has never had a drink or taken drugs, says she was once pulled over for drunk driving after a church service. “There have been times when I have had spiritual experiences where I think they must be like getting high, but without the hangover.”

[quote position=”right” is_quote=”true”]Religious or spiritual connectedness could offer protective benefits against depression.[/quote]

The Utah study did reveal some slight differences in the way the reward system lights up during religious experience that differs from drugs, however. “This wasn’t just a release of dopamine,” Ferguson clarifies. “We saw high levels of thought and abstract engagement from prefrontal regions, which we think are probably amplifying the phenomenal components of this religious experience.”

In other words, a drug experience will activate the nucleus accumbens independent of other brain regions, whereas a religious experience brings about a “coordination of regions.” While Ferguson says that a case can be made that religious experience is “habit-forming,” much like drugs or alcohol, he makes clear that “to just immediately dismiss all habit-forming behavior as vice and unhealthy is unwarranted.”

For Boston writer Britni de la Cretaz, who primarily considered herself an atheist and “a nonpracticing Jew” until she got sober, “a spiritual experience and connection with a higher power” wasn’t just a healthier habit. It was the thing that stopped her from drinking and doing drugs, she says.

“When I was an atheist, I fancied myself too smart to believe in God,” she says. Yet it was through the spiritual component of the Twelve Step recovery program, Alcoholics Anonymous, that de la Cretaz connected with a higher power and finally became sober. “I’ve been sober five years, and I credit that to forces greater than me because everything in my power I’d ever tried up until I tried believing in God hadn’t worked,” she says.

Jameelah Obadiah Schmidt, who was raised in an Islamic family, had a memorable religious moment of ecstasy in “a dream of the world ending in fire.” She says that Islam teaches that “for those who have properly prepared for and executed the five daily prayers on the Day of Judgment, there would be a glow about you.” After that dream, she says, “I never saw the world the same again. Every color was brighter, every laugh more joyful, every hug more warm and meaningful than before.”

[quote position=”right” is_quote=”true”]To just immediately dismiss all habit-forming behavior as vice or unhealthy is unwarranted.[/quote]

Even those with spiritual practices that don’t use “God” in their language, like Amy Elizabeth Robinson, a practicing Zen Buddhist, says she has felt “held by something larger than myself, larger than the apparent objective universe” as a result of her regular meditation practice.

Excited by his early results, Ferguson aims to look deeper into the “genetic, biological aspects of the dopaminergic system,” recruited in the religious experiences of his participants. “I’m very interested to understand why one person is just not susceptible to belief and they maintain states of disbelief and doubt, whereas other individuals seem to be very susceptible to speculative ideas or supernatural ideas.” He wonders if this might be linked to differences in “dopamine physiological variations.”

The idea that one’s propensity for religious experience might be rooted in biology brings some relief to Rebecca Chamaa, who attends a Lutheran Christian Church and who has schizophrenia, a brain disorder that can lead to psychosis. “Considering that there is always someone waiting to tell me I am demon-possessed—which I find cruel beyond measure—I find this oddly comforting,” she says.

[quote position=”full” is_quote=”true”]After a religious dream, I never saw the world the same again. Every color was brighter, every laugh more joyful, every hug more warm and meaningful than before.[/quote]

Chamaa, who feels closest to God when she is “contemplating or witnessing in action the teachings of Christ,” has had her most intense connections with God during her numerous psychotic episodes, and misses those conversations when they end.

“It does seem like a reasonable hypothesis that religious or spiritual connectedness could offer protective benefits against depression or feeling hopelessness, but we would need to do follow-up studies,” says Ferguson. Next up, he will work to deepen science’s understanding of religious ecstasy and euphoria by studying Catholic and Muslim populations—revealing unexplored realities about the social function of religious and spiritual experiences, grounded in biology.

  • GLP‑1 drugs may fight addiction across every major substance, according to a study of 600,000 people
    With GLP-1 drugs becoming more accessible and affordable, they could also be within reach for substance use treatment.Photo credit: Michael Siluk/Universal Images Group via Getty Images
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    GLP‑1 drugs may fight addiction across every major substance, according to a study of 600,000 people

    A massive study of veterans suggests these medications may quiet cravings far beyond food.

    A patient of mine, a veteran who had tried to quit smoking for over a decade, told me that after he started a GLP-1 drug for his diabetes, he lost interest in cigarettes. He didn’t use a patch. He didn’t set a quit date. He simply lost interest. It happened without effort.

    Another patient on one of these drugs for weight loss told me that alcohol had lost its pull – after years of failed attempts to quit.

    People struggling with many addictions, ranging from opioids to gambling, are reporting similar experiences in clinics, on social media and around dinner tables. None of them started these drugs to quit. This pattern of people losing their cravings across a broad range of addictive substances has no precedent in medicine.

    But my patients were giving me an important clue. People taking GLP-1 drugs often talk about “food noise” vanishing: the constant mental chatter about food that dominated their days simply goes quiet. But my patients were reporting that it wasn’t just food: They were noticing that the preoccupation with smoking, drinking and using drugs that drives people back despite their best intentions to stop was going quiet too.

    As a physician whose patients are often on GLP-1 drugs, and as a scientist who works on answering pressing public health questions – from long COVID to medication safety – I saw a problem hiding in plain sight: Many addictions have no approved treatment. The few medications that exist are massively underutilized, and none works across all substances. The idea that a drug already taken by millions might do what no addiction treatment has done before was too important to ignore.

    My team and I set out to test whether GLP-1 drugs – medications like semaglutide (Ozempic and Wegovy) and tirzepatide (Mounjaro and Zepbound), originally developed for diabetes and then approved for obesity – could do what no existing addiction treatment does: curb craving itself.

    Our evidence strongly suggests they can.

    Biological basis of cravings

    The hormone that these drugs mimic – GLP-1 – is not only produced in the gut. It is also active in the brain, where the receptors it binds to cluster in regions governing reward, motivation and stress – the same circuitry that gets hijacked by addiction. At therapeutic doses, GLP-1 drugs cross the blood-brain barrier and dampen dopamine signaling in the brain’s core reward center, making addictive substances less rewarding.

    GLP-1 drugs seem to inhibit cravings for several different substances in multiple animal models. For instance, rodents given GLP-1 drugs drink less alcoholself-administer less cocaine and show less interest in nicotine. When researchers gave semaglutide to green vervet monkeys – primates that voluntarily drink alcohol much like humans do – the animals drank less without showing signs of nausea or changes in water intake. This suggests the drug lowered the reward value of alcohol rather than making the animals feel sick.

    From animals to people

    To find out whether these drugs have a similar effect on people, we turned to the electronic health records of more than 600,000 patients with Type 2 diabetes at the U.S. Department of Veterans Affairs – one of the largest health care databases in the world.

    We designed a study that applied the rigor of randomized controlled trials – the gold standard in medicine – to real-world data. We compared people who started GLP-1 drugs to people who did not, adjusting for differences in health history, demographics and other factors, and followed both groups for three years.

    My team and I asked two questions: For people already struggling with addiction, did the drugs reduce overdoses, drug-related hospitalizations and deaths? And for people with no prior substance use disorder, did GLP-1 drugs reduce their risk of developing one across all major addictive substances: alcohol, opioids, cocaine, cannabis and nicotine?

    What we found was striking. In the group already struggling with addiction, there were 50% fewer deaths due to substance use among those taking GLP-1 drugs compared with those who were not. We also found 39% fewer overdoses, 26% fewer drug-related hospitalizations and 25% fewer suicide attempts. Over three years, this translated to roughly 12 fewer serious events in total per 1,000 people using GLP-1 drugs – including two fewer deaths.

    Reductions of this magnitude are rare in addiction medicine – and what’s remarkable is that the finding came from drugs initially designed for diabetes, later repurposed for obesity and never intended to treat addiction.

    The drugs also appeared to prevent addiction from developing in the first place. Among people with no prior substance use disorder, those taking GLP-1 drugs had an 18% lower risk of developing alcohol use disorder, a 25% lower risk of opioid use disorder and an approximately 20% lower risk of cocaine and nicotine dependence. Over three years, this translated to roughly six to seven fewer new diagnoses per 1,000 GLP-1 users.

    With tens of millions of people already using GLP-1 drugs, the reductions in deaths, overdoses, hospitalizations and new diagnoses could translate into thousands of prevented serious events each year.

    Converging evidence

    Our findings align with a growing body of evidence.

    A Swedish nationwide study of 227,000 people with alcohol use disorder found that those taking GLP-1 drugs had 36% lower risk of alcohol-related hospitalizations. This is more than double the 14% reduction that the same study found with naltrexone, which was the best-performing medication approved for treatment of alcohol use disorder in that analysis. Other observational studies have linked GLP-1 drugs to lower rates of new and recurring alcohol use disorderreduced diagnoses and relapse in cannabis use disorderfewer health care visits for nicotine dependence and lower risk of opioid overdose.

    Meanwhile, randomized controlled trials that directly test whether these drugs help people with addiction also show promise. In one trial, semaglutide reduced both craving and alcohol consumption in people with alcohol use disorder. In another, dulaglutide reduced drinking. More than a dozen additional trials are already underway or actively enrolling, and several more are planned.

    The future of addiction treatment

    GLP-1 drugs are the first type of medication to show potential benefit across multiple substance types simultaneously. And unlike existing addiction medications, which are prescribed by specialists and remain vastly underused, GLP-1 drugs are already prescribed at enormous scale by primary care doctors. The delivery system to reach millions of patients already exists.

    The consistency of GLP-1 effectiveness across alcohol, opioids, cocaine, nicotine and cannabis suggests these drugs may act on a shared vulnerability underlying addiction – not on any single substance pathway. If confirmed, that would represent a fundamental shift in how society understands addiction and how doctors treat it.

    Some unanswered questions remain, though, about how these drugs would affect addiction. Many people who take GLP-1 drugs to treat obesity or diabetes discontinue them; afterward, their appetite typically returns and they regain the weight they lost. Whether the same rebound would occur with addiction, and what it would mean for someone in recovery to face the roar of craving again, is unknown. Nor is it clear whether the benefits persist over years of continuous use, or whether the brain adapts in ways that dampen those effects.

    Also, because GLP-1 drugs engage the brain’s reward circuitry – the same system that governs not just craving but everyday motivation – prolonged use could, in theory, dampen motivational drive in some people. Whether that might affect real-world outcomes, such as initiative, competitive drive or performance at work, remains an open question.

    What comes next

    GLP-1 drugs have not been approved for addiction, and there is not yet enough evidence to prescribe them solely for that purpose. But for millions of people already weighing whether to start a GLP-1 drug for diabetes, obesity or another approved indication, it is one more factor worth considering.

    A patient living with diabetes who is also trying to quit smoking might reasonably choose a GLP-1 drug over another glucose-lowering medication, not because it is approved for smoking cessation, but because it may help them quit, a benefit that other diabetes drugs do not offer. Similarly, for people living with obesity who also struggle with alcohol, the potential for benefit beyond weight loss could be one more reason to consider a GLP-1 drug.

    If additional trials confirm that they effectively curb cravings across addictive substances, these drugs could begin to close one of the most consequential treatment gaps in medicine. And the most promising lead in addiction in decades will have come not from a deliberate search but from patients reporting a benefit no one anticipated. Like my patient who quit smoking after a lifetime of trying, it happened without effort.

    This article originally appeared on The Conversation. You can read it here.

  • Expert shares ancient monk’s mindset for keeping your composure when life ‘bumps’ you
    Coffee spill (LEFT). Man upset with shirt stain (RIGHT).Photo credit: Canva

    A snap reaction in a heated moment can be difficult to control. Sometimes an unexpected experience brings out the best in us—or, all too often, the worst. The Mindset Mentor Podcast, hosted by personal coach Rob Dial, explains how cultivating a healthy mindset can help you stay calm and composed when life “bumps” into you.

    Using a story of an ancient monk teaching his students about enlightenment, Dial highlights that whatever we carry within ourselves rises to the surface when life gets hard. Beginning the day with a healthy mindset matters.

    Dial shares a monk’s story about enlightenment

    A monk teaches his students about enlightenment. He asks them to imagine holding a cup of coffee when someone bumps into them, causing it to spill. When he asks why the coffee spilled, the students quickly reply that it was because someone bumped into them.

    The monk responds, “You spilled the coffee because that’s what was in your cup. Had there been water in the cup, you would have spilled water. Had there been tea in the cup, then you would have spilled tea.”

    Dial goes on to explain the impactful meaning behind the monk’s simple philosophy:

    “When life shakes you, which it will, whatever you carry inside of you will spill out. So if you’re carrying anger, or fear, or hatred, or jealousy, then that is what is going to spill out of you in those moments. But, if you’re carrying love and kindness and compassion and empathy, then that is what is going to spill out you.”

    morning practice, mediation, mindset, mental health
    An early morning stretch.
    Photo credit: Canva

    A question to ask before your day

    If this is the challenge we face each day, the real question becomes: how do we prepare ourselves for what life might throw our way? Dial suggests the answer lies in an intentional pause. “Each morning,” he says, “it’s important for you to stop and close your eyes and ask yourself, ‘What am I carrying inside of me today?’”

    That small act of self-awareness can shape everything that follows. If we choose to bring despair, judgment, and negativity, those emotions will most likely surface when things don’t go as planned. But if we choose to center ourselves in kindness and compassion, we’re far more likely to respond with those qualities instead.

    Positive thinking, affirmations, skills,
community
    Good Morning.
    Photo credit: Canva

    The advantages of morning preparation and a healthy mindset

    Significant time and research have gone into understanding the benefits of a morning routine. These practices help build a kind of “spiritual armor” that prepares us to face the day with confidence. Simple habits like getting sunlight, drinking water, moving our bodies, and practicing mindfulness can boost energy and improve mood.

    A 2024 study found that morning activities like loving-kindness meditation can positively affect people’s mental health. Individuals with a regular practice tend to be more positive, mindful, and compassionate. The length or specific details of the practice have little effect on outcomes when compared with one another.

    Another 2024 study found that framing problems in a positive way helps people recover faster from stress. Staying motivated during difficult situations and feeling more emotionally stable are skills that can be built through mindset. The simple fact is that study after study demonstrates that positive thinking directly supports mental health during difficult periods in life.

    Dial offers a simple concept: what we carry within ourselves influences how we respond to life’s challenges. The students say it’s because they were bumped. The monk explains it’s what’s in the cup. The real preparation for the day isn’t just what we do, it’s what we choose to carry. “What am I carrying today?”

    You can watch this short video on starting a morning meditation practice:

  • The Tsimané people of Bolivia have almost no dementia. Scientists say modern life is our problem.
    A tribe sharing a mealPhoto credit: Canva

    Deep in the Bolivian Amazon, researchers studying two indigenous communities have found something that stopped them in their tracks: among older Tsimané adults, the rate of dementia is roughly 1%. In the United States, the figure for the same age group is 11%.

    The finding, published in the journal Alzheimer’s & Dementia, is part of nearly two decades of research on the Tsimané and their sister population the Mosetén, communities who have been recorded as having some of the lowest rates of heart disease, brain atrophy, and cognitive decline ever measured in science. A subsequent study from the University of Southern California and Chapman University, published in the Proceedings of the National Academy of Sciences, used CT scans on 1,165 Tsimané and Mosetén adults to measure how their brains age compared to populations in the US and Europe. The answer was striking: their brains age significantly more slowly.

    The researchers’ explanation centers on what they call a “sweet spot” — a balance between physical exertion and food availability that most people in industrialized countries have drifted far from. “The lives of our pre-industrial ancestors were punctuated by limited food availability,” said Dr. Andrei Irimia, an assistant professor at USC’s Leonard Davis School of Gerontology and co-author of the study. “Humans historically spent a lot of time exercising out of necessity to find food, and their brain aging profiles reflected this lifestyle.”

    The Tsimané people of Bolivia posing for a photograph.
    The Tsimané people of Bolivia posing for a photograph. Photo credit: Canva

    The Tsimané are highly active not because they exercise in any structured sense but because their daily lives demand it. They fish, hunt, farm with hand tools, and forage, averaging around 17,000 steps a day. Their diet is heavy on carbohydrates — plantains, cassava, rice, and corn make up roughly 70% of what they eat, with fats and protein splitting the remaining 30%. It is not a low-carb or protein-heavy regimen. It is, essentially, the diet of people who burn what they consume. CNN’s Dr. Sanjay Gupta, who visited a Tsimané village in 2018 for his series “Chasing Life,” noted that they also sleep around nine hours a night and practice what might be called intermittent fasting — not by choice, but by necessity during lean seasons.

    The research also included the Mosetén, who share the Tsimané’s ancestral history and subsistence lifestyle but have more access to modern technology, medicine, and infrastructure. Their brain health outcomes fell between the Tsimané and industrialized populations, better than Americans and Europeans, but not as strong as the Tsimané. Researchers describe this gradient as especially revealing because it suggests a continuum rather than a binary, and that even partial movement toward a more active, less calorically abundant lifestyle appears to have measurable effects on how the brain ages.

    “During our evolutionary past, more food and less effort spent getting it resulted in improved health,” said Hillard Kaplan, a professor of health economics and anthropology at Chapman University who has studied the Tsimané for nearly 20 years. “With industrialization, those traits lead us to overshoot the mark.”

    The researchers are careful to note that the Tsimané lifestyle is not simply transferable. Their longevity in absolute terms is lower than Americans’ because of deaths from trauma, infection, and complications in childbirth, hazards of living without a healthcare system. The point of the research is not that modern medicine is unnecessary but that the environments it’s embedded in may be undermining the brain health it’s trying to protect.

    “This ideal set of conditions for disease prevention prompts us to consider whether our industrialized lifestyles increase our risk of disease,” Irimia said.

    This article originally appeared earlier this year.

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