How Studying Canine Osteoarthritis is Providing Insight for Healthier Human Bones, Too

This series is brought to you by our partner, Purina ONE®. These stories share the innovations that are changing how we care for and learn from our pets. Read more about how pets—and the people who love them—can brighten lives and strengthen our communities at the GOOD Pets hub.

Before you think osteoarthritis (OA) has nothing to do with you until you’re older, learn why improving your health now could benefit your bones later. In fact, you might as well make this an even more productive learning experience by getting on a stationary bike or taking some vitamins while you read this. Yes, without frequent movement and proper nutrients, you’re more at risk for your joints to break down and possibly lead to chronic painful inflammation associated with OA. But, how can we be sure of that and how are researchers studying and deciphering these processes?

Man’s best friend has provided insight to uncover some important clues. Although only 12 percent of the human population aged 25 to 74 eventually develop OA, 20 percent of the general canine population also suffers from this chronic degenerative disease, according to Osteoarthritis Research Society International. And because canine joints pretty much work the same way as human joints, scientists have hypothesized, and now proven, that canine OA develops in a very similar way to human OA.

In 2002, Dr. Rondo Middleton, a senior research scientist at Nestlé Purina Research Center, collected cells from canine hip bones that had been discarded from hip replacement surgeries at Ohio State University. With a high-tech microscope slide known as a canine microarray, Middleton identified more than 300 differences between arthritic states, leading to a better understanding of how OA affected the canine body.

It was a game-changer to be able to identify and study the enzymes that were responsible for tearing down bad cartilage and building new cartilage, as well as the lifecycle of a healthy cell to an arthritic one.

“It allowed us to target the key players in the cells, rather than just the symptoms of the disease,” Steven Hannah, Head of Molecular Nutrition at the Nestlé Purina Research Center, says. “Prior to our studies, canine OA was understood to a certain degree. We knew damaged cartilage wasn’t being repaired correctly, but by letting the cell tell us what was happening to it, we could finally confirm that damage and inflammation were huge components of OA.”

So by finally proving what many assumed, Middleton and Hannah could now explore possible treatments for OA.

“We grew the cells in a petri dish, then caused them to move toward an arthritic state using certain molecular challenges. This model was used to examine nutritional candidates, such as omega-3 fatty acids, that might prevent the cells from becoming arthritic,” Hannah says. To confirm the anti-inflammatory properties of omega-3 fatty acids in not only petri dishes, but also arthritic dogs, Hannah and Middleton fed a diet rich in omega-3 fatty acids to dogs in a clinical study with collaborators at Colorado State University’s School of Veterinary Medicine. “And voilà the omega-3 fatty acids got to the joints like we thought they would and the arthritic dogs, by various means, told us they felt better,” Hannah says.

Now, scientists are able to study how such nutrients might play a preventative role in the development of the disease. “This work supports the idea that we don’t just necessarily need to throw medications at every issue, and we can actually minimize the amount of medical intervention if we leverage the nutritional management side,” Hannah says.

In other words, adding more fish rich in omega-3 fatty acids to the diets of both dogs and humans with OA may help reduce the amount of medicine they have to take later down the line. And for those without OA, it doesn’t hurt to eat some salmon for dinner tonight, or make it a weekly habit. It might help your bones later down the line.

Image via (cc) Flickr user Faul

via Affinity Magazine / Twitter

Disgraced movie mogul Harvey Weinstein has been found guilty of rape in the third degree and criminal sexual acts in the first degree in New York City.

The jury was unanimous in its convictions as well as two not-guilty verdicts on predatory sexual assault charges involving actress Annabella Sciorra.

The Miramax co-founder may spend the rest of his natural life behind bars.

Keep Reading
via Jim Browing / YouTube

Jim Browning is a YouTuber from the UK who has an amazing ability to catch scammers in the act.

In this video, he responds to a scam email claiming he bought a laptop by breaking into the scammer's computer. In the process he uncovers where the scammers work, their banking information, and even their personal identities.

"I got an 'invoice' email telling me that I had paid for a $3800 laptop," Browning writes on his YouTube page. "No links... just a phone number. It's a real shame that these scammers emailed me because I was able to find out exactly who they were and where the were."

Keep Reading

A two-minute television ad from New Zealand is a gut punch to dog lovers who smoke cigarettes. "Quit for Your Pets" focuses on how second-hand smoke doesn't just affect other humans, but our pets as well.

According to Quitline New Zealand, "when you smoke around your pets, they're twice as likely to get cancer."

Keep Reading