Most of us have known a person who has or is facing cancer. It’s a brutal disease that kills millions of people every year. There have been many attempts to find solutions to a seemingly never ending problem. Scientists have been studying a new discovery that seems very promising. It involves a process called pyroptosis, and it’s the new rallying topic in cancer research.

Scientists have found a sugar compound produced by tiny microbes living in the ocean. This deep-sea bacteria named Spongiibacter nanhainus CSC3.9 produce mannose and glucose, sugar, that can target specific cancer cells caused by a strain of human leukemia. This sugar specifically seeks out the cancer tumor and causes it to rupture and die. It was also found to be effective in a study targeting liver cancer found in mice.

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Cancer cell image provided by Harvard University. media0.giphy.com

According to the study presented in Science Daily by Wiley, “This natural substance, produced by microbes living in the ocean, causes cancer cells to undergo a fiery form of cell death, essentially making them self-destruct. In lab tests and in mice with liver cancer, the compound not only stopped tumors from growing, but also activated the immune system to fight back. This finding could pave the way for entirely new cancer treatments based on sugars from marine organisms.”

What is Pyroptosis?

explosion, cell, microbiology, studies, cancer treatments, pyroptosis, immune system
Cell explosion. media1.giphy.com

Pyroptosis is a process in which the cells basically self destruct. As stated in the article, “Pyroptosis is a fiery form of programmed cell death that helps the body fight infections and disease. Unlike regular cell death (apoptosis), pyroptosis is dramatic and explosive—cells swell, burst open, and release inflammatory signals that alert the immune system.” The idea being that the bodies natural immune system will target the ruptured cancer cells. Almost as if the tumor itself is the rallying signal for the body to eliminate the problem.

The FASEB Journal shared a research article which spoke on the potential of tumor treatments through pyroptosis. The sugar, active exopolysaccharide, is highly common in Spongiibacter making it a readily usable resource. The article writes, “This study provides an important theoretical basis for EPS3.9 as a new type of marine carbohydrate anti-tumor drug candidate and also provides scientific evidence for the feasibility and potential of tumor treatment by triggering pyroptosis.”

What redditors have to say about the promising discovery?

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Hands holding a symbol foru00a0breast cancer, au00a0pink ribbon. Image via Canva – Photo by Ave Calvar Martinez

The pain and anger around science and its inability to solve the cancer crisis was relatively strong through the thread. People often feel disillusioned as every year we hear about new amazing discoveries and have yet to witness the benefits. Here are some of the things they said:

  • “Anyone else kinda irritated it seems these big headlines always come about some huge cancer breakthrough yet nothing materializes from it? With all the so called breakthroughs and huge amount of funding you would think a cure would be found. Sounds tinfoil hat but almost seems there is something actively working stymie a cure.”
  • “There’s no ‘cure for cancer’ because cancer isn’t one thing, it’s thousands of somewhat similar conditions of faulty cellular division and explosive growth.”
  • “Every cancer is different so there will not be one cure. My husband’s cancer was caused by a really specific failing of his immune system and the thing that fixed that is not going to fix, say, leukemia. But the incremental changes are making a difference.”
  • “Don’t worry Kennedy will find this as unhealthy and ban it immediately.”
  • “Stuff like this makes me think about how stupid we are for being so destructive to our world. We’re just dumb monkeys playing who’s the King of the Castle, too primitive to see that our ‘castle’ is just a huge pile of our own crap.”

There are many feelings to be had around science and its ability to solve important issues. This groundbreaking marine-derived treatment shows promising results in lab tests. It will hopefully pave the way for a new class of anti-cancer therapies.

  • Probability underlies much of the modern world – an engineering professor explains how it actually works
    ​Probability can explain why a coin flip has a 50/50 chance of landing heads versus tails, but it also can be used for more powerful applications.Photo credit: Monty Rakusen/DigitalVision via Getty Images
    Zachary del Rosario

    Zachary del Rosario

    Probability underpins AI, cryptography and statistics. However, as the philosopher Bertrand Russell said, “Probability is the most important concept in modern science, especially as nobody has the slightest notion what it means.”

    I teach statistics to engineers, so I know that while probability is important, it is counterintuitive.

    Probability is a branch of mathematics that describes randomness. When scientists describe randomness, they’re describing chance events – like a coin flip – not strange occurrences, like a person dressed as a zebra. While scientists do not have a way to predict strange occurrences, probability does predict long-run behavior – that is, the trends that emerge from many repeated events.

    Mathematics, Education, Explainer, Statistics, Probability, Frequency, Doing science
    We may say ‘random’ to describe strange occurrences (person dressed as zebra), but probability describes chance events (a coin flip).Photo credit: Zebras in La Paz, Bolivia by EEJCC, Own Work CC A-SA 4.0; CC BY-SA

    Modeling with probability

    Since probability is about events, a scientist must choose which events to study. This choice defines the sample space. When flipping a coin, for example, you might define your event as the way it lands.

    Coins almost always land on heads or tails. However, it’s possible – if very unlikely – for a coin to land on its side. So to create a sample space, you’d have two choices: heads and tails, or heads, tails and side. For now, ignore the side landings and use heads and tails as our sample space.

    Next, you would assign probabilities to the events. Probability describes the rate of occurrence of an event and takes values between 0% and 100%. For example, a fair flip will tend to land 50% heads up and 50% tails up.

    To assign probabilities, however, you need to think carefully about the scenario. What if the person flipping the coin is a cheater? There’s a sneaky technique to “wobble” the coin without flipping, controlling the outcome. Even if you can prevent cheating, real coin flips are slightly more probable to land on their starting face – so if you start the flip with the coin heads up, it’s very slightly more likely to land heads up.

    In both the cheating and real flip cases, you need an appropriate sample space: starting face and other face. To have a fair flip in the real world, you’d need an additional step where you randomly – with equal probability – choose the starting face, then flip the coin.

    Mathematics, Education, Explainer, Statistics, Probability, Frequency, Doing science
    The probabilities for different coin-flipping scenarios.Photo credit: Zachary del Rosario, CC BY-SA

    These assumptions add up quickly. To have a fair flip, you had to ignore side landings, assume no one is cheating, and assume the starting face is evenly random. Together, these assumptions constitute a model for the coin flip with random outcomes. Probability tells us about the long-run behavior of a random model. In the case of the coin model, probability describes how many coins land on heads out of many flips.

    But instead of using a random model, why not just solve the coin toss using physics? Actually, scientists have done just that, and the physics shows that slight changes in the speed of the flip determine whether it comes up heads or tails. This sensitivity makes a coin flip unpredictable, so a random model is a good one.

    Frequency vs. probability

    Probability differs from frequency, which is the rate of events in a sequence. For example, if you flip a coin eight times and get two heads, that’s a frequency of 25%. Even if the probability of flipping a coin and seeing heads is 50% over the long run, each short sequence of flips will come out different. Four heads and four tails is the most probable outcome from eight flips, but other events can – and will – happen.

    Frequency and probability are the same in one special setting: when the number of data points goes to infinity. In this sense, probability tells us about long-run behavior.

    Mathematics, Education, Explainer, Statistics, Probability, Frequency, Doing science
    Probabilities for all possible outcomes of eight ‘fair’ coin flips.Photo credit: Zachary del Rosario, CC BY-SA

    Applications to AI, cryptography and statistics

    Probability isn’t just useful for predicting coin flips. It underlies many modern technological systems.

    For example, AI systems such as large language models, or LLMs, are based on next-word prediction. Essentially, they compute a probability for the words that follow your prompt. For example, with the prompt “New York” you might get “City” or “State” as the predicted next word, because in the training data those are the words that most frequently follow.

    But since probability describes randomness, the outputs of a LLM are random. Just like a sequence of coin flips is not guaranteed to come out the same way every time, if you ask an LLM the same question again, you will tend to get a different response. Effectively, each next word is treated like a new coin flip.

    Randomness is also key to cryptography: the science of securing information. Cryptographic communication uses a shared secret, such as a password, to secure information. However, surprising randomness isn’t good enough for security, which is why picking a surprising word is a bad choice of password. A shared secret is only secure if it’s hard to guess. Even if a word is surprising, real words are easier to guess than flipping a “coin” for each letter.

    You can make a much stronger password by using probability to choose characters at random on your keyboard – or better yet, use a password manager.

    Finally, randomness is key in statistics. Statisticians are responsible for designing and analyzing studies to make use of limited data. This practice is especially important when studying medical treatments, because every data point represents a person’s life.

    The gold standard is a randomized controlled trial. Participants are assigned to receive the new treatment or the current standard of care based on a fair coin flip. It may seem strange to do this assignment randomly – using coin flips to make decisions about lives. However, the unpredictability serves an important role, as it ensures that nothing about the person affects their chance to get the treatment: not age, gender, race, income or any other factor. The unpredictability helps scientists ensure that only the treatment causes the observed result and not any other factor.

    So what does probability mean? Like any kind of math, it’s only a model, meaning it can’t perfectly describe the world. In the examples discussed, probability is useful for describing long-term behaviors and using unpredictability to solve practical problems.

    This article originally appeared on The Conversation. You can read it here.

  • Researchers capture sperm whales headbutting on camera, validating what sailors have said for centuries
    Sperm whales headbutting.Photo credit: University of St Andrews/YouTube
    ,

    Researchers capture sperm whales headbutting on camera, validating what sailors have said for centuries

    “It’s exciting to think about what as-yet unseen behaviours we may soon uncover”

    For centuries, sailors have told wild tales of whales ramming ships. Reports of a sperm whale smashing and sinking the Essex in 1820 inspired Herman Melville to write Moby-Dick. Scientists had never witnessed it themselves—until now.

    Researchers have captured the first-ever drone footage of sperm whales headbutting each other. During fieldwork off the coast of the Balearic Islands, they recorded three separate incidents between 2020 and 2022.

    Drone footage captures sperm whales headbutting

    The new study was published in the journal Marine Mammal Science. Using drones, researchers from the University of St Andrews, the University of the Azores, and Asociación Tursiops captured video evidence of sperm whales headbutting. They found that most of the whales were young, immature males. In one incident, a young male circling near a female suddenly charged and slammed into her, knocking her off course. After the impact, she broke away from the group and did not return.

    The researchers estimated impact speeds ranging from 1.8 to 8 miles per hour, with collisions generating forces of up to 20 tons of pressure. The impacts captured on video were not necessarily considered aggressive. In fact, researchers believe the behavior reflects rough play or forms of mock combat. Similar behaviors can be seen in other mammals, like dolphins and lions.

    sperm whales, Moby Dick, literature, history, whaling
    A depiction of Moby-Dick.
    Photo credit: Canva

    Observations of sperm whale behavior

    Using their large heads, sperm whales have been reported by whalers to strike and move objects since the 19th century. “It was really exciting to observe this behaviour, which we knew had been hypothesised for such a long time, but not yet documented and described systematically,” said Dr. Alec Burslem, lead author of the study.

    “It’s exciting to think about what as-yet unseen behaviours we may soon uncover, as well how more headbutting observations may help us to shed light on the functions the behaviour may serve,” Burslem added.

    Documented, unprovoked attacks on humans by sperm whales are exceedingly rare, with most occurring during historical whaling incidents. Research indicates that sperm whales do not naturally exhibit aggression toward humans. While they can be curious, they often avoid vessels and observers. Historical accounts of whales ramming ships are likely defensive reactions rather than predatory attacks.

    ocean mammals, sperm whales, non-aggressive behavior, language, social structures
    A sperm whale.
    Photo credit: Canva

    Language and cultural identities

    Whales use clicks like letters, combining them into sequences that function like words in a complex form of communication. A 2024 study found that sperm whales use a highly sophisticated communication system with structures resembling a phonetic alphabet. These audio cues are used for coordination, caregiving, and social interaction.

    A 2022 study found that specific click patterns serve as symbolic markers that help establish cultural identities within sperm whale pods. Researchers identified seven distinct clans, each with its own unique dialect. This provided quantitative evidence of whale social structures known as identity codas.

    Studying this new drone footage offers fresh insights into whale social groups and behavior. While the headbutting may look aggressive, researchers interpret it as rough play. With technologies like drones giving scientists unprecedented access to these interactions, it’s exciting to think of what discoveries are yet to be made.

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